INDEX 



581 



Richct and Portier's work 



n anaphylaxis, 

 360 



Richet's work on passive 

 anaphylaxis, 380 



Riein, "protein-free," 97 



Romer's method for diph- 

 theria antitoxin 

 s t a ndardization, 

 401 



"Root-tubercle" bacilli, 7 



Rosenau and Anderson, re- 

 searches of, in 

 bacterial anaphy- 

 laxis, 412 



work on anaphylaxis, 

 362, 374 et seq. 



Rosenow on variations in 

 streptococci, 474 



Roux and Yersin, experi- 

 mental immuniza- 

 tion in hog chol- 

 era by, 72 



Rowland's antiplague se- 

 rum, 482 

 vaccine in prophylactic 



1 m m u n i zation 

 against plague, 

 489 



Russell's vaccines for pro- 

 phylactic immuni- 

 zation against ty- 

 phoid fever, 485 



Salt-inactivation of alexin, 



178 



Salts, effect of, in agglu- 

 tination, 243 

 in precipitation, 265 

 Saprophytes, biological 



transition of, to 

 parasites, 5 

 occurrence of, 2 

 pathogenic powers of 



certain, 4 

 pure, 11 



Saprophytic micro-organ- 

 isms, definition of, 

 4 



Scarlet fever, relative sus- 

 ceptibility of man 

 and animals to, 

 54 



Schmidt, precipitation ex- 

 periments of, on 

 heat precipitins, 

 260, 261 

 Sensibilisin, 387 

 Stnsibilisinogen. 387 

 Sensitization. 134, 359 

 Bordet's views on, 162, 



163 

 complement deviation in, 



160 



Ehrlich and Sachs's phe- 

 nomenon in, 165 

 Bordet and Cray's in- 

 terpretation of, 

 166, 167 



Ehrlich and Sachs's 

 views on, 164, 

 165 



Neisser-Wechsberg phe- 

 nomenon in. 160 

 Sensitized bacteria, immu- 

 nization with. 68 

 Sensitized tuberculin. 357 

 Sensitized vaccines, 355 

 Sensitizer. See Ambocep- 



tor 



Bordet's definition of, 

 159 



Sensitizer, quantitative de- 

 termination of. in 

 immune serum, 

 160, 161 



Septicemia, chronic, adap- 

 tation of bacteria 

 in, 7 



secondary foci in, 7 

 Serum; See also Blood 



serum 



activities of, 523 et sc<i. 

 antitoxic, direct effect 

 of, on toxin, 104 

 indirect protective ac- 

 tion of. against 

 toxin, 104 

 bactericidal powers of, 



79, 134 



bactericidal properties 

 of, in immunity, 

 81 



resistance and, 297 

 cell-free, bacterial 



growth in, 81 

 immune, bacteriotropins 

 in. without lysins, 

 322 



heated, reactivation 

 of. by addition of 

 alexin. 318 



opsonins in, bacteri- 

 cidal sensitizers 

 and, 321 et seq. 

 heated, increase of 

 power of. by ad- 

 dition of fresh 

 normal serum, 

 318 



increase of, 315 

 normal opsonins 



and. 320 et seq. 

 specificity of. 321 

 phagocytosis in, 91, 



increase of, 311. 

 See also Phagocy- 

 tosis 

 normal, agglutinins in, 



91 



antic omplementary 



properties of, 196 



hemolytic properties 



of, 91 

 o p s o n i c powers of, 



314 

 reduction of, by 



heat, 314 

 opsonins in, 91 



cooperation of heat- 

 stable and heat 

 sensitive body in, 

 318, 319 

 nature of, 316 

 resistance of. to 



heat, 315 

 similarity of, to 



alexin. 316, 317 

 specificity of, 318 

 thormostability of. 



320 

 specific thermostable 



opsonins in, 317 

 normal antitoxic, diph- 

 theria, 107 



opsonins in normal and 

 immune, qualita- 

 tive differences in, 

 315, 316 



reactions, physical fac- 

 tors in. 535 

 Serum sickness, 428 



analogy of anaphylaxis 

 with, 430 



Serum sickness, antibody 



formation in, 431 



incubation time in, 



431 



methods of administra- 

 tion of antitoxin 

 to avoid, 432 

 Besredka's method of, 



433 

 by alteration of serum, 



432 

 Friedberger and Mita's 



method of, 434 

 in animal experimen- 

 tation, 433 



with concentrated an- 

 titoxin, 432 



von Pirquet and Schick's 

 studies of, 429 et 

 seq. 

 symptoms of, 428 



accelerated reaction of 

 von Pirquet and 

 Schick in, 429 

 after first injection, 



428 

 after second injection, 



429 

 immediate reaction in, 



429 



analogy of, to ana- 

 phylaxis, 429 



Serum therapy, anaphylax- 

 is in. See Serum 

 sickness 



in diphtheria, 448. See 

 also Diphtheria 

 antitoxin 



in diseases caused by 

 bacteria which do 

 not form soluble 

 toxins, 468 



action of serum upon 

 extensive infec- 

 tion in. 469 

 antibacterial action in, 



468 



in epidemic cerebrospinal 

 meningitis, 471 

 See also under 

 Cerebros pinal 

 meningitis, e p i - 

 demic 



in plague, 480. See also 

 Plague, serum 

 therapy of 



in pneumonia, 476. See 

 also pneumonia, 

 serum therapy 

 in 



in streptococcus infec- 

 tions, 473. See 

 also under Strep- 

 tococcus i n f e c - 

 tions 



in typhoid fever, 477. 

 See also Typhoid 

 fever, serum ther- 

 apy of 



Side chain theory, 124 

 anti-body production in 

 body cells in, 130 

 body cell in, 125 



chemical nature of. 



126 

 "Leistungskern" in, 



126 



side chains or recep- 

 tors in, 126 



chemical action of anti- 

 gens in. 128 



definition of side chains, 

 in, 126 



