582 



INDEX 



Side chain theory, diagram 

 showing cell-re- 

 ceptors and im- 

 raune bodies 

 (Ehrlich) in. 127 

 in toxin-antitoxin reac- 

 tion, 124 



overproduction of recep- 

 tors in, 129 

 flow of, into blood a 

 cause of immu- 

 nity, 128 

 physical mechanism of, 



124 



recapitulation of. 130 

 relationship between 



susceptibility of 

 tissue and toxin- 

 binding properties 

 in, 131 



Skin, defence of, in infec- 

 tion, 12 



Skin infections, local im- 

 munity in, 103 

 Small-pox, active prophy- 

 lactic immuniza- 

 t i o n against. 

 490 

 Jenner's discovery of, 



490 



production and prep- 

 aration of vac- 

 cine for, 491 

 history of experimenta- 

 tion in immuniza- 

 tion against, by 

 Jenner, 62 



relative susceptibility of 

 man and animals 

 to, 54 

 vaccination for, history 



of, 62 



principles of. 62 

 Smith, Theobald, investiga- 

 tions of, in ana- 

 phylaxis. 363 

 phenomenon of, in ana- 



phylaxis. 361 

 Snake venoms. 36 

 action of, 467 

 Activation of. by endp- 

 complement in 

 blood cells, 174 

 by sera, 174 

 antitoxins for. 466 



e ff e c t of heat on, 



ion 



immunization against, 



466 

 K y e s ' experiments in. 



174, 175 



neurotoxins in. 467 

 peculiarities of. 466 

 toxin-antitoxin combina- 

 tion in, stability 

 of. 105 



toxin-antitoxin reaction 



with. 105. 467 



filtration experiments 



in. 105 

 neutralization theory 



of, 105 

 time element in, 



105 



toxin-HCl modification 

 of, effect of heat 

 on, 106 

 Sols. 544 



Species resistance, 51 

 Specific hyperleukocytosia 



309 



Specificity, definition of, 76 

 Spermatotoxins, 92 



Spleen, , removal of, and 

 antibody - forma- 

 tion in active im- 

 munity, 101 

 and susceptibility to 



infection. 101 

 Standardization of anti- 

 toxin, guinea pigs 

 used in. 108 

 minimum lethal dose in, 



109 



Standardization of diph- 

 theria antitoxin, 

 by means of tox- 

 in, 107 



early attempts at. 107 

 unit in, 107 



Standardization of sera, 

 Pfeiffer's method 

 of, 139 

 Standardization of tetanus 

 antitoxin by 

 means of toxin, 

 107 



Standardization of vac- 

 cines. 352 



Hopkins' method of, 353 

 Wright's method o f, 



352. 353 

 Staphylococcus furunculo- 

 sis, opsonic index 

 in vaccine treat- 

 ment of, 335 

 Staphylococcus infections, 

 opsonic index in. 

 334 



during vaccine treat- 

 ment with dead 

 s t a p h y lococcus 

 cultures, 335 

 relative susceptibility of 

 man and animals 

 to, 54 



Stern's modification of 

 Wassermann test. 

 209 



Stimulins. 311 

 Strauss test, 25 

 Streptococci variations in, 



474 



Streptococcus infections, 

 agglutination re- 

 action in diag- 

 nosis of, 222 

 relative, of man and 



animals, 54 

 serum therapy in 473 

 difficulties in, owing 

 to variations of 

 streptococci, 473, 

 474 

 early investigations in, 



474 

 Marmorek's work on, 



474. 475 

 nature of action in, 



475 



standardization of se- 

 rum in. 476 

 value of, 475 



Strong's investigations in 

 prophylactic im 

 munization 

 against plague. 

 490 



method of prophylactic 



vaccination i n 



cholera, 489 



Sub-infection, 24, 234 



"Summation of negative 



phase" in active 



i m m u n i z ation 



338. 339 



'Summation of positive 

 phase" in active 

 immunization, 339 

 Surface tension in chcmo- 



taxis, 293 

 Susceptibility, body tem- 

 perature and, 51 

 cultural conditions for 

 bacteria in body 

 and, 50 



increased invasive pow- 

 ers of bacteria 

 and, 56 

 individual differences 



. and. 58 

 inheritance a factor in, 



56 

 racial differences in, 



55 

 relative, of animals to 



infection, 51 



species resistance to in- 

 fection and, 51 

 Sycosis, opsonic index in 

 vaccine treatment 

 of, 336, 337 

 Syntoxoids, 116 

 Syphilis, autoinoculation 



in. 500. 502 

 Colles' law, 499 

 colloidal gold reaction 



in, 539 



diagnosis of, Bordet-Gen- 

 gou phenomenon 

 in, 188 

 by alexin fixation. 



198, 199, 512 

 by direct precipita- 

 tion of syphilitic 

 serum by emul- 

 sions of lecithin 

 and of sodium 

 glycocholate, 204 

 "ideal fall" in, 503 

 immunity in, 498, 511. 



512 



Profeta's law. 499 

 reinfection in, 502 

 reinoculation in, 500, 



502 



relative susceptibility of 

 man and animals 

 to, 52, 505, 508 

 resistance of animals to, 



508 



superinfection in, 499 

 transmission of, to ani- 

 mals, 505 



ultramicroscopic method 

 of finding precipi- 

 tates in sera of. 

 204 

 vaccination against, 



511 



Wassermann reaction in, 

 diagnostic value 

 of. 210, 211, 512. 

 513 



technique of, 207 

 Bauer's modification 



of. 209 



Noguchi's modifica- 

 tion of. 208. 209 

 schematic presen- 

 tation of. 209 

 Stern's modification 

 of, 209 



T.. definition of. 109 

 Temperature, body, and re- 

 sistance to infec- 

 tion, 51 



