INDEX 



583 



Tetanus, "cryptogenic," 5 

 relative susceptibility of 

 man and animals 

 to, 53 



toxin, fixation in, by 



brain tissues, lol 



lipoidal substances 



a factor in, 133 

 proteolytic enzymes 



a factor in, 133 

 temperature a fac- 

 tor in, 132 



Tetanus antitoxin, produc- 

 tion of, 405 



standardization ot. 4(>> 



by means of toxin, 10 < 



Tetanus bacillus, action ot, 



4, 5 

 Tetanus toxin, action ot, 



41 



Thread reaction of Pfaund- 

 ler in agglutina- 

 tion, 222, 223 

 Thymotoxin, 92 

 Thyroid gland, production 



of alexin in, 172 

 production of opsonins 



in. 173 

 Toxemia, 10 



bacterial, 423 



Toxicity, definition of, 11 

 Toxic unit, definition of, 



109 



Toxin-antitoxin, diphthe- 

 ria. See Diph- 

 theria toxin-anti- 

 toxin 



Toxin-antitoxin combina- 

 tion, chemical re- 

 lations of, 114 

 effect of heat on, 106 

 in snake venom, stabil- 

 ity of. 105 

 toxin-HCl modification 



of, 106 

 effect of heat on 



106 



measurement of, by par 

 t i a 1 absorption 

 method of Ehr 

 lich, 115 

 stability of, 105 

 valency of componen 



parts of, 114 

 Toxin-antitoxin reaction, 



104 



analogy between chemi- 

 cal reactions and. 

 118, 119 



antibody production in 

 body cells in, 130 

 body cells in, 125 



chemical nature of. 



126 



chemical action of anti- 

 gens in, 128 

 concentration of rea- 

 gents in, 107 

 degrees of toxicity in. 



123 



direct neutralization the 

 protective power 

 of, 124 



effect of heat on, 105 

 effect of temperature on. 



104 



mechanism of, 104 

 neutralization in. ab- 

 sorption theory 

 of, 123 



Arrhenius and Mad- 

 sen on, 120 

 Bordet on, 122 



Toxin-antitoxin reaction, 

 neutralization in, 

 Bordet' -D a n y s z 

 phenomenon in, 

 123 

 von Dungern's views 



on, 124 



Danysz effect in. 123 

 phenomena of, 119 ct 



seq. 



overproduction of recep- 

 tors in, 128 

 flow of, into blood a 

 cause of immu- 

 nity, 128 

 physical mechanism of, 



124 

 quantitative relations in, 



106, 123 



relationship between sus- 

 ceptibility of tis- 

 sue and toxin- 

 binding properties 

 in, 131 

 side chain theory in, 



124 



specificity of, 124 129 

 speed of action of, 10 < 

 time element in, 105 

 with snake venom, lOo 

 filtration experiments 



in, 105 

 neutralization theory 



of, 105 



time element in, 105 

 Toxin, bacterial. See Bac- 

 terial toxins 

 chemical relations of, 

 with antitoxin, 

 114 

 deterioration theory of 



110, 111 



definition of, 32 

 differences in combining 



avidity of. Ill 

 diphtheria, construction 



of, 118 

 normal, 107 

 direct effect of antitoxic 



serum' on, 104 

 epitoxoid form of, 112 

 indirect effect of anti 

 toxic serum on 

 104 



structure of, 110 

 toxoid, 110 



prototoxoids in. 115 

 syntoxoids in, 116 

 toxon. 113 

 true, 33 



analogy of. with en 



zymes, 36 



bacteria producing. 3 

 characteristics -of. 34 

 chemically indefinab 



nature of. 35 

 diseases for whic 

 some investigatoi 

 claim. 471 

 heat sensitiveness o 



36 



incubation time of. 

 production of ant 



toxin by. 35 



Toxin hypersusceptibilit 

 anaphylaxis an 

 409 

 Toxin spectra, constru 



tion of, 116 

 definition of, 116 

 measurement of, 11 



117 

 principles of, 116 



oxin unit, definition of, 



109 



diphtheria, 107 

 oxoids, definition of, 110 

 "oxons, action of, 113 

 definition of, 113 

 structure of, 113 

 oxophore group of toxin, 



110 



action of, 110 

 ropins, 311 



ubercle bacilli, effect of 

 body temperature 

 on virulence of, 12 

 uberculosis, avian type, 

 relative suscepti- 

 bility of animals 

 to, 52 



bovine type, relative sus- 

 ceptibility of man 

 and animals to, 52 

 complement fixation test 

 in diagnosis . of, 

 217 



human type, relative 

 susceptibility o f 

 man and animals 

 to, 52 



meiostagmin reaction in 

 diagnosis of, 538 

 of cold-blooded animals,' 

 immunity of 

 warm-blooded ani- 

 mals to, 52 

 opsonic index in, 341- 



342, 343 

 Tuberculin ophthalmoreac- 

 tion, anaphylactic 

 nature of, 442 

 Tuberculin reaction, anal- 

 ogy of, to ana- 

 phylaxis. 444 

 anaphvlactic nature of. 



'440 



Bail's experiments with 

 passive sensitiza- 

 tion in, 445 



diagnostic value ot, 444 

 Koch's experiments in, 



441 

 nature of, 440 



Babes' interpretation 



of, 441 

 Koch's interpretation 



of, 441 



Wassermann and 

 Brucks interpre- 

 tation ot. 441 

 specific antibody forma- 

 tion in, 444 



Tuberculin skin reaction, 

 anapnylactic na- 

 ture of, 442 



von Pirquet's interpreta- 

 tion of, 443 

 Tuberculins. 355 



Bouillon Filtre (Denys). 



357 

 New Tuberculin (TR 



and TO), 356 

 New Tuberculin Bacilla- 

 ry Emulsion. 35 < 

 Old Tuberculin (Koch). 



355 

 sensitized Tuberculin, 



357 



Tumors, malignant, alexin 

 fixation in diag- 

 nosis of, 213 

 von Dungern's method 



of. 214 



antigen production 

 for. 214 



