584 



INDEX 



Tumors, malignant, alexin 

 fixation in diag- 

 nosis of, results 

 of, 215 

 technique of, 214 et 



seq. 

 organ-specific qualities 



in, 373 



Typhoid bacilli, attenua- 

 tion of virulence 

 of, 18 



toxicity of, 423 

 Typhoid carriers, 3 

 Typhoid fever, adaptation 



of bacteria in, 8 

 agglutination reaction 

 for diagnosis of, 

 219 

 macroscopic method, 



219 

 microscopic method, 



220 



effect of path of intro- 

 duction of bac- 

 teria of, on infec- 

 tion. 14 



meiostagmin reaction in 

 diagnosis of, 53* 

 prophylactic immuniza- 

 tion against, ac- 

 tive, 484 

 early experimentation 



in, 484 



living sensitized vac- 

 cines used in. 48(5 

 results of* in United 

 States Army. 4S5 

 Russell's vaccines in, 



485 



sensitized killed vac- 

 cines in. 486 

 relative susceptibility of 

 man and animals 

 to, 54 



serum therapy in. 477 

 Besredka's anti-endo- 

 toxic serum in, 

 478 



Chantemesse's early 

 experiments i n, 

 477 

 Garbat and Meyer's 



work on. 479 

 Kraus and Stenitzer's 



serum in, 479 

 Gottstein - M a t h e s ' 



work on. 479 

 Liidke s work on. 479 

 nature of reaction in, 



478 

 vaccine treatment in, 



486 



Typhus fever, relative sus- 

 ceptibility of man 

 and animals to, 54 



Ultramicroscope, 547 



Vaccination, prophylactic, 

 in man. 483 



in anthrax, 64 



in cholera. 487. See also 

 under Cholera 



in paratyphoid fever, 

 484 



in plague, 489. See also 

 under Plague 



in rabies. 492. See also 

 under Rabies 



in small-pox. 491. See 

 also under Small- 

 pox 



Vaccination, prophylactic, 

 in smallpox, his- 

 tory and general 

 principles of, 62 

 in typhoid fever, 484, 

 486. See also un- 

 der Typhoid fever 

 Vaccine therapy. See also 

 Immunization, ac- 

 tive 



anaphylaxis in, 434 

 as a therapeutic meas- 

 ure, action of, in 

 local infections, 

 346 



in generalized sys- 

 temic infections, 

 347 

 in successive local 



infections. 347 

 value of. in acute dis- 

 eases. 350 



in subacute or 

 chronic cases, 349 

 autoinoculations by mas- 

 sage or exercise 

 in, 340 

 "high tide" of immunity 



in, 340 



"negative" phase in, 338 

 second injection in, 



338 - 



successive inocula- 

 tions in, 338, 339 

 summation of, 338, 



839 

 opsonic index in, 328 et 



seq. 



comparison between 



that in exudate of 



infected foci and 



blood serum. 340 



improvement and, 



341 

 in tuberculosis, 341- 



343 



Leishmann's technique 

 for determination 

 of,. 329 



Simon, Lamar and 

 Bispham's tech- 

 nique for deter- 

 mination of. 332, 

 333 

 value of. 338 



in controlling thera- 

 p e u t i c vaccina- 

 tions. 344 



in showing degree 

 and conditions in 

 which vaccination 

 is successful, 344, 

 345 



Wright's technique for 

 determination of, 

 330 et seq. 

 difficulties in, 332, 



333 



value of. 333 

 relation of phagocytosis 



to. 329 

 second positive phase in, 



339 

 "Summation of positive 



phase" in. 339 

 tuberculins in, 355 

 value of, as prophylactic 

 measure, 345, 

 346 



as therapeutic meas- 

 ure, 346 



Vaccines, autogenous, 351 

 production of, 351 



Vaccines, production of, 

 with dead bac- 

 teria, 351 

 with living bacteria, 



351 



sensitized, 355 

 standardization of, 352 

 Hopkins' method of, 



353 

 Wright's method of, 



352, 353 



Vaughan's work on ana- 

 phylaxis, 366. 367 

 on bacterial anaphylaxis, 



Vaughan and Wheeler, pro- 

 teid split prod- 

 ucts of, in ana- 

 phylactic poison, 

 405 



theory of, on mechanism 

 of anaphylaxis, 

 390 



work of. on toxic frac- 

 tion of protein 

 molecule in ana- 

 phylaxis. 390 



Virulence, aggressin secre- 

 tion of bacteria 

 in body and. 20-22 



capsule formation of 

 bacteria and, 18 



definition of, 11 



dependent on resistance 

 of bacteria to leu- 

 kocytes in pha- 

 gocytosis. 325 



differentiated from toxi- 

 city, 11 



ectoplasmic hypertrophy 

 of bacteria in re- 

 lation to, 19. 20 



effect of body tempera- 

 ture on, 12 



effect of cultural adap- 

 tation of bacteria 

 on, 12 



effect of path of intro- 

 duction of bac- 

 teria on, 12-14 



effect of quantity of bac- 

 teria introduced 

 on, 14 



increase of, by attenua- 

 tion of bacteria, 

 17 



measurement of relative 

 degrees of. 15 



of capsulated bacteria, 

 326 



relation of, to phagocy- 

 tosis, 312 



relative to number of 

 bacteria i n t r o - 

 duced, 15 



specificity of bacteria 

 and, 22 



variation in. of bacteria 

 successively 

 passed through 

 animals, 16. 17 

 of different strains of 

 snme bacteria, 15, 

 16 



Virulins. 22. 326 

 "Virus fixe" in treatment 



of rabies. 492 

 Vital resistance, 524 



Wassermann reaction, 198 

 alexin fixation principle 

 in, 198 



