PHENOMENA FOLLOWING IMMUNIZATION 103 



due to yeasts or blastomyces, in which, as the writer has seen, the 

 apparent lack of liberation of toxic products gives rise to a purely 

 local giant-cell reaction, adjacent tissue cells remaining undegener- 

 ated and apparently unaffected. In the case of infection with bac- 

 teria like the bacillus of tuberculosis, the leprosy bacillus, that of 

 rhinoscleroma, and a few others the purely local picture of giant- 

 cell phagocytosis is complicated by secondary reactions arising prob- 

 ably from the liberation of toxic products from the living or dead 

 invaders which both stimulate specific cell reactions and call forth 

 cell degeneration in adjacent tissues, frequently giving the individual 

 infection a diagnostically characteristic appearance. 



