BACTERICIDAL PROPERTIES OF Hi .' SERUM 157 



/o 



1>< e active in the given case. Thus, altln iigUrsiicli a polyceptor, 

 :rse, is capable of uniting with the complement which activates 

 the lominant complement, it is capable also 

 of union with a number of other comple- 

 meits which have slight or no functional 

 acf.on whatever the non-dominant com- 

 plements. This opinion is rendered dia- 

 grtmmatic by Ehrlich and Marshall 53 , in 

 th* following way : 



If one carefully considers the reaso.ns 

 advanced for the assumption of the < 

 teice of such polyceptors it does not soem 

 they are sufficiently forcible to/ lead 

 one to desert the much simpler exjj/lanation 

 of Eordeu 



Related to the problems discussed in 



ection with 

 t h " production 



of a antlrrabo- ( c ) Dominant Complement. 

 ,, (d) Secondary Complements. 



^^Tkf /-VTK3- ' OT 9.n- X -, AIM /-T j; 



" < Complementophile Groups ot 

 the Amboceptor: 



(1) for the Dominant Com- 

 plement. 



(2) for the Secondary Com- 

 plement. 



f After Ehrlich and Marshall, 

 - Berl. Min. Wocli., No. 

 5, 1902.) 



POLYCEPTOR ACCORDING TO 

 EHRLICH AND MARSHALL. 



(a) Keceptor of the Cell. 



(b) Haptophore Group of 

 the Amboceptor. 



ceptors" 

 t i sensi 

 are those which^ 

 have arisen re- 

 garding the ex- 

 istence of "anti- 

 complement" or 

 "anti - alexins." 



Ehrlich and Morgenroth Claimed that, by 

 the injection of active horse serum into a 

 goat, they had obtained substances in the 

 goat serum which neutralized hGse com- 

 plement. They believed that the "'^nti- 

 complements" thus produced neutralized 

 the complement by uniting with its hapto- 

 phore group, thus preventing its combina- 

 tion with the "complementophile group" 

 of the amboceptor. This was their con- 

 clusion because they found that the "anti- 

 complementary" serum exerted no protec- 

 tive influence upon sensitized cells, when 

 these were exposed to the serum and then 

 removed, but that it protected against 

 hemolysis when added to the cells together 



with the complement. There was apparently no union of the pro- 

 tective substance with the "complementophile" group of the ambo- 

 53 Ehrlich and Mai-shall. Berl. kl Woch., No. 25, 1902. 



P]HRLICH AND MORGEN- 

 ROTH 7 s CONCEPTION OF 

 THE ACTION OF ANTI- 

 COMPLEMENT. 



A. Scheme of Hemolysis. 



B. Action of Anticomple- 

 ment upon Hemolysin. 



b. = blood cell, c. = com- 

 plement, i. = immune 

 body, a. = anticomple- 

 ment. 



The complernentoids are 

 not included in the 

 scheme, since in this 

 case they are without 

 influence. 



