164 



INFECTION AND RESISTANCE 



mental importance in its contradiction of the regularly progressive 

 quantitative relations which strict adherence to the "armSoceptor" 

 idea would seem to impose. 



The quantitative relations here outlined have been diagrammat- 

 ically represented hy Noguchi as follows : 



20 units of A/nboceofor 

 used /n eacfi comti/natton 



Green . Complement 

 Purple Amboceptor 

 fad /feemo/sij 



/unit of Amboceptor 

 used /n each w/rn various 

 fractions ofa complement 



I 





NOGUCHI 's DIAGRAM ILLUSTRATING THE QUANTITATIVE EELATIONS BETWEEN ANTI- 

 GEN, AMBOCEPTOR AND COMPLEMENT. 



(Taken from Noguchi, "Serum Diagnosis of Syphilis," Lippincott, Philadelphia, 



1910.) 



The essential point of difference between the opinions of Ehrlich 

 and Bordet concerning the processes of hemolysis and bacteriolysis 

 lies, as we have seen, in the conception of the union of alexin or com- 

 plement with amboceptor or sensitizer. Although Ehrlich and his 

 followers admit that the union of complement with amboceptor does 

 not usually occur unless the amboceptor has previously united with 

 the antigen, they still maintain that this may occasionally take place 



