ANAPHYLAXIS 409 



ture, since this, as we shall see, is equally impossible in the case of 

 tuberculin susceptibility, which is in all probability a modified exam- 

 ple of true anaphylaxis. Lowi and Meyer regard tetanus toxin hyper- 

 susceptibility as a "summation" meaning thereby that it depends 

 upon an alteration of the cells of the spinal cord because of traces of 

 the poison retained in them. When the toxin was given intraneurally 

 no antitoxin formation occurred, but the animals developed a marked 

 hypersusceptibility in the course of several weeks, showing that 

 here, unlike true anaphylaxis, specific antibodies play no part. 



Not unlike toxin hypersusceptibility is that which is noticed in 

 the case of certain medicinal substances. Such are the so-called 

 idiosyncrasies against cocain, pilocarpin, morphin, quinin, and other 

 drugs. These conditions have no direct relation to anaphylaxis, and, 

 according to Hans Meyer, 81 depend probably upon the chemical 

 peculiarities of the tissues of the individual, such as calcium con- 

 tents, etc. Hunt 82 has also shown that poison susceptibility, in cer- 

 tain cases, may be influenced by the diet. 



81 Meyer u. Gottlieb. "Experimentelle Pharmakologie," 2d Ed., Urban 

 & Schwartzenberg, pp. 520 et seq., 1911. 



82 Reid Hunt. U. S. Pub. Health and M. H. S. Hyg. Lab. Bull. 69, 1910. 



