CLINICAL SIGNIFICANCE OF ANAPHYLAXIS 445 



of malignant tumors. Together with Finsterer 59 he sensitized 

 guinea pigs with the serum of carcinomatous patients following the 

 injection 48 hours later with press-juices of tumors. His conclu- 

 sions were drawn from the anaphylactic temperature reaction, and 

 he claims that animals so sensitized are hypersusceptible to the 

 juices obtained from carcinomata, whereas animals sensitized with 

 normal serum or the serum of sarcoma patients show no hypersus- 

 ceptibility. Ranzi 60 has not been able to confirm this. The signifi- 

 cance of such experiments, if correct, apart from their practical 

 value for the diagnosis of carcinoma, would be considerable in that 

 they tend to show that cancer tissues contain a specific protein 

 which is antigenically distinct from the other tissue-proteins of 

 the afflicted individual. However, we cannot yet accept these facts 

 as absolutely established. 



59 Pfeiffer and Finsterer. Wien. klin. Woch., No. 28, 1909. 



60 Ranzi. Zeitschr. f. Imm., Yol. 2, 1909. 



