530 



INDEX OF SUBJECTS 



Anaphylaxis, toxin hyper- 

 susceptibility and, 

 407 



transference of, 362, 379 

 et seq. 



true antigen-antibody re- 

 action, 390 



tuberculin ophthalmo-re- 

 action and, 440 



tuberculin reaction and, 

 438. See also Tu- 

 berculin reaction 



tuberculin skin reaction 

 and, 440 



Vaughan and Wheeler's 

 theory of mechanism 

 of, 393 



Vaughan and Wheeler's 

 work on toxic 

 fraction of pro- 

 tein molecule in, 

 393 



Vaughan's work on, 366, 

 367 



Weichhardt and Schit- 

 tenhelm's work 

 on, 369, 370 



with bacterial extracts, 

 363 



with normal serum, 362 



with proteins, 362 

 Anaphylaxis, bacterial, 410 



anaphylatoxin formation 

 in, 413. See also 

 under Anaphyla- 

 toxin. 



difference of speed of re- 

 action of sensi- 

 tized and unsen- 

 sitized bacteria 

 in, 418 



endotoxin theory of pro- 

 duction of, 412 



Friedberger's experi- 



ments in, 413, 414 

 facts deduced from, 



415 



effect of excess of 

 bacteria adminis- 

 tered in, 415 

 effect of excess of 

 sensitization on 

 anaphylatoxin in, 

 415 



effect of too pro- 

 longed exposure 

 in anaphylatoxin 

 in, 416 



nature of bacterial in- 

 fections and, 419 

 et seq. 



Neufeld and Dold's ex- 

 periments in, 417 



serum anaphylaxis and, 

 411 



Vaughan's theory of bac- 

 terial splitting as 

 cause of, 412, 413 

 Anaphylaxis, passive, 379 

 et seq. 



Biedl and Kraus's work 

 on, 383 



Doerr and Russ's work 

 on, 380 



duration of, 381 



Friedemann's work on, 

 380, 381, 383 



Gay and Southard's 

 work on, 380 



interval between injec- 

 tion of sensitized 

 serum and injec- 

 tion of antigen in, 

 382 



Anaphylaxis, passive, 

 methods of pro- 

 duction of, 380, 

 381 

 nature of reaction of, 



382 



Nicolle's work on, 380 

 Otto's work on, 380 

 Richet's work on, 380 

 Weill-Halle" and Le- 

 maire's work on, 

 382, 383 



Anderson and Schultz's 

 work on anaphy- 

 laxis, 365 



Anthrax, relative suscepti- 

 bility of man and 

 animals to, 53 

 study of, in regard to 

 resistance and 

 immunity, 296 

 vaccination against, his- 

 tory of, 64 

 method of, 64 

 Anthrax bacilli, attenua- 

 tion of virulence 

 of, 18 



virulence of, 15 

 Anti-alexin, 157 

 action of, 157 

 Anti-amboceptor, 152, 153 

 Anti-anaphylaxis, 362, 377 

 Besredka's work on, 375 



et seq. 

 mechanism of, 401 et 



seq. 



desensitization in, 401 



tolerance to anaphy- 



lactic poison in, 



402 



methods of producing, 



377 



Besredka and Stein- 

 hardt's methods, 

 377 



Rosenau and Ander- 

 son's methods, 378 

 specificity of, 378, 403 

 "Anti-antibodies," 147 

 Antibodies, concentration 

 of. in lymphatic 

 organs in active 

 immunity, 100 

 in other organs in ac- 

 tive immuniza- 

 tion. 101 

 . in active immunization, 



85 



locality of production 

 'of, dependent on 

 locality of anti- 

 gen concentra- 

 tion, 101 

 normal, explanation of, 



234 



origin of, 100 

 specificity of, 85 

 Antibody formation, body 



cell in, 125 

 chemical nature of, 



126 



chemical action of anti- 

 gens in, 128 



in active immunity, re- 

 moval of spleen 

 and, 100 



mechanism of (side 

 chain theory), 124 

 by internal secretion 

 of body cell, 125 

 processes of metabol- 

 ism and, 125 

 overproduction of recep- 

 tors in, 128 



Antibody formation, prin- 

 ciples of, 94 

 Anticomplement, 157 



action of. 157 

 Anticytophile interpreta- 

 tion of anti-sensi- 

 tization (Ehrlich 

 and Morgenroth), 

 153 



controversy on, 153 

 "Antiformin," 70 

 Antigen-antibody reactions, 

 129. See also 

 Toxin - antitoxin 

 reaction. 



antibody production in 

 body cells in, 130 

 relationship between 

 susceptibility of 

 tissue and toxin- 

 binding properties 

 in, 131 

 side chain theory in, 



129 



specificity of, 97, 129 

 variety of antibodies in, 



129 



agglutinins, 129 

 antitoxins, 129 

 cytotoxins, 129 

 precipitins, 129 

 Antigenic properties of 

 cells, relation of, 

 to lipoid constit- 

 uents, 97 



Antigens, action of, 95 

 active immunization 

 with, analogies to 

 drug tolerance, 

 99 



characteristics of, vari- 

 ations in, 98 

 complex structure of, 

 Ehrlich and Mor- 

 genroth's concep- 

 tion of, 151 

 definition of, 35, 94 

 "local" immunity in or- 

 gans directly in 

 contact with, 

 101 



locality of production of 

 antibodies depen- 

 dent on locality 

 of concentration 

 of, 101 



organ specificity of, 98 

 protein nature of, 96 

 specificity of, 97 

 Anti-isolysins, 147 

 "Antiricin," 85 

 Antisensibilisin, 387 

 Antisensitization, anti- 

 cytophile interpre- 

 tation of (Ehrlich 

 and Morgenroth), 

 153 



controversy on, 153 

 Antisensitizers, 152, 153 

 non-specificity of, 154 

 Antitoxic serum, direct ef- 

 fect of, on toxin, 

 104 



indirect protective ac- 

 tion of, against 

 toxin, 104 

 "normal" serum of Behr- 



ing, 107 



Antitoxin, chemical rela- 

 tions of, with 

 toxin, 114 



definition of, 85, 86 

 diphtheria. See Diph- 

 theria antitoxin. 



