INDEX OF SUBJECTS 



531 



Antitoxin, production of, 



129 



by true toxins, 35 

 snake venom, 464 



effect of heat on, 105 

 specific, substances in- 

 citing, 86 

 standardization of, 



463 

 by means of toxin, 



107 

 guinea pigs used in, 



108 

 tetanus, production of, 



463 



use of, in passive im- 

 munization, 86 

 Antitoxin unit, diphtheria, 



107 



Antivenin, 464 

 Arrhenius and Madsen on 

 neutralization in 

 toxin - antitoxin 

 reaction, 120 

 Arthus, phenomenon of, 



380 

 work of, on anaphylaxis, 



361 



Ascoli and Izar's work on 

 meistagmin reac- 

 tion, 496 



Asiatic cholera, relative 



susceptibility of 



man and animals 



to, 53 



Asthma, anaphylaxis and, 



434 



Atrepsie, 56 

 Attenuation of bacteria by 



chemicals, 66 

 by cultivation under 



pressure, 66 

 by drying, 65 

 by heating, 65 

 by passage through ani- 

 mals, 65 



by prolonged cultivation 

 above optimum 

 temperature, 65 

 by prolonged growth on 

 artificial media in 

 presence of own 

 metabolic prod- 

 ucts, 65 

 capsule formation in, 



18 



Auer and Lewis's work on 

 anaphylaxis, 364 

 Autocy totoxins, 93 . - 6 "J 

 Autogenous vaccines, 351 

 "A u t o hemolysins," 146, 



147 



Auto-inoculation by mas- 

 sage in active 

 immunization, 340 

 Autolysins, 146 

 Autosensitization in ana- 

 phylaxis, 373 

 Auxilysin, 167 

 Avian tuberculosis, relative 

 susceptibility of 

 animals to, 52 



Bacillus botulinus, action 



of, 4 

 Bacteria, adaptation of, in 



body, 6, 7 



agglutinability of, alter- 

 ations in. 226 

 by cultivation in 

 immune serum, 

 228 



Bacteria, agglutinability 

 of, caused by 

 heating, 226 

 normal differences 

 in, between 

 strains of same 

 species, 228, 229 

 spontaneous, 227 

 in agglutinoid, 229 



agglutination in. See 

 under Agglutina- 

 tion. 



"agglutinin" bacteria, 

 agglutination of, 

 243 



aggressin secretion of, 

 in body, and vir- 

 ulence of, 20-22 



anti-opsonic properties 

 of, and antichem- 

 otactic sub- 

 stances, 325 



artificial cultivation of, 

 10 



attentuation of, 18 

 methods of. 65. See 

 also under Atten- 

 uation. 



by laboratory ma- 

 nipulations, 17 



capsulated, agglutination 



of, 243 

 virulence of, 326 



capsule formation in, 

 and virulence, 18 



colloid phenomena and 

 action in, 516 



destruction of, by cy- 

 tases in leuko- 

 cytes, 301, 302 

 by exudates, 300 

 by phagocytes, 300 



different strains of, va- 

 riation in infec- 

 tion from, 15, 16 



ectoplasmic hypertrophy 

 of, in relation to 

 virulence, 19. 20 



effect of body tempera- 

 ture on invasive 

 powers of, 12 



effect of cultural adap- 

 tation of, on vir- 

 ulence, 12 



effect of path of intro- 

 duction of. on 

 infection, 12-14 

 on virulence of, 12-14 



effect of quantity of, in- 

 troduced, on in- 

 fection, 14 



entrance of, into body 

 tissues, 6 



generalized action of, 24 



growth of, within leu- 

 kocytes, 298 



in blood stream, 24 



in localized infection, re- 

 action to, 26 

 through accidental 

 conditions. 25 



in normal serum, resis- 

 tance to phagocy- 

 tosis of, 325 



incubation of. 26 



localized action of, 23 



measurement of relative 

 degrees of viru- 

 lence of, 15 



negative charge of, in 

 suspension, 242 



number of, introduced, 

 and relative viru- 

 lence, 15 



Bacteria, occurrence of, 2 



parasitic and saprophy- 

 tic, classification 

 of. 11 



phagocytosis of. See 

 under Phagocyto- 

 sis. 



relative virulence of dif- 

 ferent strains of 

 same, 15, 16 



resistance of, to phago- 

 cytosis, due to 

 nonabsorption of 

 opsonin, 326 



resistance of living cell 

 to, 6 



secondary abscesses 

 caused by, 25 



selective action of, in 

 localized infec- 

 tion. 25 



selective lodgment of, in 

 tissues, 40 



sensitized, immunization 

 with, 68 



sensitized and unsensi- 

 tized, influence of 

 salts on aggluti- 

 nation of, 243, 

 244 



similar conditions pro- 

 duced by differ- 

 ent, 23 



specificity of, and infec- 

 tion, 22 



use of, in active immu- 

 nization, 85, 87- 

 89 



variation in virulence of, 

 when successively 

 passed through 

 animals. 16, 17 

 Bacterial anaphylaxis. See 

 Anaphylaxis, bac- 

 terial. 



Bacterial extracts, active 

 immunization 

 with, 69 



extraction of bacteria 

 for, by mechan- 

 ical methods, 71 

 by permitting them 

 to remain in fluid 

 media, 70 



Bacterial infections, con- 

 ceived as reac- 

 tion of body 

 against a foreign 

 antigen, 420 



nature of (Friedberger), 



419 et seq. 



Bacterial precipitins, group 

 reactions in. 251 

 diagnostic value of, 

 252 



partial or minor, 252 

 Bacterial products, active 

 i m muni zation 

 with, 72 



Bactericidal properties of 

 blood serum, 134 

 Bacterial proteins, 33 

 Bacterial toxins. See also 

 Toxins. 



action of, after distribu- 

 t i o n in body, 

 40 



active immunization 

 with, 72 



chemical structure of, 

 in relation to tox- 

 icity, 43 



endotoxins. See Endo- 

 toxins. 



