534 



INDEX OF SUBJECTS 



Complement, amboceptor 

 and, quantitative 

 ratio between. 



163, 164 



union of, Ehrlich and 

 Sachs's views on, 



164, 165 

 definition of, 144 



in hemolysis, 144 

 multiplicity of, 154 et 



seq. 



Bordet's views on, 156 

 Ehrlich's views on. 



155 



nature of, 354 

 chemical, 174 

 Complement deviation, 160 



et seq. 



argument in favor of 

 Bordet's views, 

 162, 163 



colloid reactions, analo- 

 gous to, 162 

 Gay's explanation of, 



163 

 in hemolytic reactions, 



163 



Morgenroth and Sachs's 

 experiments sup- 

 porting, 163 

 pro-agglutinoid zone re- 

 action analogous 

 to, 162 



Complement fixation, 186. 

 See also Alexin 

 fixation. 



in determination of na- 

 ture of unknown 

 protein, 211 

 delicacy of, 212. 213 

 technique of, 212 

 practical applications of, 



198 

 test of, in diagnosis of 



glanders, 216 

 in diagnosis of gonor- 

 rheal infections, 

 216 



in diagnosis of malig- 

 nant neoplasms, 

 213 



von Dungern's 

 method of, 214 

 antigen produc- 

 tion for, 214 

 results of, 215 

 technique of, 214 



et seq. 



Complement splitting, 178. 

 See also under 

 Alexin, splitting 

 of. 



Complementoid, 158 

 Complementophile group 

 of amboceptor. 

 149 



Conglutinin, 167 

 Conjunctiva, susceptibility 

 of, to infection, 

 13 

 Corpus luteum cytotoxin, 



92 



"Cryptogenic tetanus," 5 

 Cultivation of bacteria, ar- 

 tificial, 10 



Cytases, in phagocytes, de- 

 struction of bac- 

 t e r i a by, 301, 

 302 



Cytolysins, 92 

 Cytolytic substances, ori- 

 gin of, from leu- 

 kocytes, 169 et 

 seq. 



Cytophile group of ambo- 

 ceptor, 149, 152, 

 153 



Cytotoxins, 92 

 specificity of, 92 



Danysz effect in neutral- 

 ization in toxin- 

 antitoxin reac- 

 tion, 123 



Danysz toxin-antitoxin 

 phenomenon, ap- 

 plication of col- 

 loid phenomena 

 to, 517 



Daphnia, Metchnikoff's 



study of, 274, 296 

 phagocytosis in, 296 

 Dean's antiplague sera, 



480 



Denys and Leclef on im- 

 portance of phag- 

 ocytosis in im- 

 munity, 311. 312 

 Diphtheria, active immu- 

 nization in, with 

 toxin - antitoxin, 

 458 



relative susceptibility of 

 man and animals 

 to, 53 



Diphtheria antitoxic ser- 

 um, normal, 107 

 Diphtheria antitoxin, 446 

 antitoxin production in, 



455 



concentration of, 457 

 presence of, in blood of 

 normal individ- 

 uals. 448 



preservation of, 108 

 speed in administration 



of, 447 

 speed in absorption of, 



449 



on intravenous injec- 

 tion, 449, 450 

 on subcutaneous in- 

 jection. 449, 450 

 speed of diagnosis for, 

 necessity of, 451 

 stability of, 108 

 standardization of, 455 

 by means of toxin, 



107 



early attempts in, 107 

 statistics showing reduc- 

 tion of mortality 

 with, 446 



toxin production for, 452 

 choice of culture in, 



452 

 cultivation of strain 



in, 452, 453 

 culture medium in, 



453 

 "maturing" of toxin 



in, 453 

 testing of toxin in, 



454 

 Theobald Smith's 



method of, 454 

 unit of, 107 

 Diphtheria bacillus, action 



of, 4, 5 

 Diphtheria toxin, action 



of, 40 



construction of, 118 

 determination of diph- 

 theria immunity 

 with, 462 

 normal, 107 

 stability of, 108 



Diphtheria toxin, unit of, 



107 



Diphtheria toxin-antitoxin, 

 neutral mixtures 

 of, 458 



Behring's method of im- 

 munization with, 

 458 



advantages of, 459 

 chief value of, 459 

 danger of anaphylaxis 



in, 459 



determination of pres- 

 ence of free tox- 

 in or antitoxin in 

 convalescents fol- 

 lowing treatment 

 with, 462 

 human susceptibility to, 



459 



production of homolo- 

 gous antitoxin in 

 human beings 

 with, for passive 

 i m m u n i zation, 

 460 

 results of treatment 



with, 460 



standardization of anti- 

 toxin, 460, 461 

 limes-necrosis of toxin 



in, 461 

 Romer's method of, 



461 



toxic action of, 458 

 Doerr and Russ's experi- 

 ments on two sep- 

 arate substances 

 in anaphylactic 

 antigen, 388 



Doerr and Russ's work on 

 passive anaphy- 

 laxis, 380 



Dochez and Gillespie's 

 work on serum 

 therapy in pneu- 

 monia, 475 



Drug tolerance, analogy 

 between, and ac- 

 tive immunization 

 with antigens, 

 99 

 Dunbar's work on hay 



fever, 434 



von Dungern's method 

 of alexin fixation 

 in diagnosis of 

 malignant tu- 

 mors, 214 

 antigen production in, 



214 



results of, 215 

 technique of, 214 et 



seq. 



"Dust cells" of the lungs 

 in phagocytosis, 

 279 



Dysentery, agglutination 

 reaction in diag- 

 nosis of, 221 



Ehrlich, conception of 

 alexin fixation 

 (schematic) o f, 

 187 



of relation of antigen, 

 amboceptor and 

 complement, 149, 

 150 



interpretation of agglu- 

 tination by, 234 



diagrammatic repre- 

 sentation of, 235 



