INDEX OF SUBJECTS 



537 



Immunization, bacteria 

 used in, 85, 87-89 



bacteriolysins in, 89 



by means of living but 

 attenuated cul- 

 tures, 65 



concentration of anti- 

 fa o d i e s in lym- 

 phatic organs in, 

 100 



in other organs in, 

 101 



definition of, 63 



"exhaustion theory" of, 

 83 



"high tide" of immunity 

 in, 340 



in diphtheria, with tox- 

 in-antitoxin mix- 

 tures, 458. See 

 also Diphtheria 

 toxin-antitoxin. 



invasion of bacteria in, 

 mechanism of re- 

 action in tissue 

 cells against, 102 



locality of production of 

 antibodies depen- 

 dent on locality 

 of antigen con- 

 centration i n , 

 101 



negative phase in, 338 

 second injection in, 



338 

 successive inoculations 



in, 338, 339 

 summation of, 338, 

 339 



non-bacterial antitoxin- 

 stimulating sub- 

 stances in, 86, 87 



"osmotic theory" of, 84 



phagocytosis in, 90 



phenomena following, 

 82 



precipitin formation in, 

 90 



reaction of tissue cells 

 to invasion in, 

 102 



removal of spleen in, 

 and antibody-for- 

 mation, 100 



"retention theory" of, 

 83 



second positive phase 

 in, 339 



specificity of antibodies 

 in, 85 



summation of positive 

 phase in, 339 



tuberculins in, 355 



vaccines in, 351 

 production of, 351 

 sensitized. 355 

 with dead bacteria, 



351 

 with living bacteria, 



351 

 standardization o f, 



353 

 Hopkins' method of, 



353 



Wright's method of, 

 352, 353 



with antigens, analogy 

 between drug tol- 

 erance and. 99 



with bacterial extracts, 



69 



extraction of bacteria 

 for, by mechan- 

 ical methods, 71 



Immunization, with bac- 

 t e r i a 1 extracts, 

 extraction of bac- 

 teria for, by per- 

 mitting them to 

 remain in fluid 

 media, 70 



with bacterial products, 

 72 



with dead bacteria, 68 

 methods used in kill- 

 ing bacteria for, 



ing 



68 



with fully virulent cul- 



tures in sublethal 



amounts, 66-68 

 with sensitized bacteria, 



68 

 Immunization, active pro- 



phylactic, in man, 



481 

 against cholera, 484. See 



also under Chol- 



era. 

 against plague, 486. See 



also under Plague 

 against rabies, 489. See 



also under Rabies 

 against small-pox, 488. 



See also under 



Small-pox 

 against typhoid fever, 



482. See also 



under Typhoid fe- 



ver 



Immunization, passive, 74 

 antitoxins in, 86 

 definition of, 64 

 history of, 74 

 in diphtheria. See Diph- 



theria antitoxin 

 in diseases caused by 



bacteria which do 



not form soluble 



toxins, 466. See 



also under Serum 



therapy. 

 therapeutic application 



of, 75 

 toxin-antitoxin reaction 



in, 104 

 underlying principles of, 



75 

 Immunized animals, bac- 



teriolysis in. 137 

 summary of facts in, 



138 



Incubation of bacteria, 26 

 Infection, acquired resis- 



tance to, 60 

 adaptation of bacteria 



in tissues in, 6, 7 

 aggressin secretion of 



bacteria in body 



and, 20-22 

 body temperature and, 



ol 

 capsule formation of 



bacteria and, 18 

 chronic, adaptation of 



bacteria in, 8 

 clinical manifestations 



of. 28 

 conjunctiva susceptible 



to. 13 



criteria governing, 3 

 cultural conditions for 



bacteria in body 



and, 56 

 defence of intestinal 



tract in, 12 

 defence of mucous mem- 



branes in, 12. 13 

 defence of skin in, 12 



Infection, definition of, 5, 

 6 



different, produced by 

 same bacteria, 23 



effect of body tempera- 

 ture on invasive 

 powers of bac- 

 teria in. 12 



effect of cultural adap- 

 tability of bac- 

 teria on, virulence 

 of, 12 



effect of path of intro- 

 duction of bac- 

 teria on, 12-14 



effect of quantity of 

 bacteria intro- 

 duced on, 14 



entrance of bacteria in 

 body tissues in, 6 



focus in, 7-9 



from bacteria in blood 

 stream, 24 



generalized, 24 



increased invasive pow- 

 ers of bacteria a 

 factor in, 56 



incubation of bacteria 

 in. 26 



individual differences 

 and, 56 



inheritance and resis- 

 tance to, 56 



localized, 23 

 reaction in, 26 

 selective action of 



bacteria in, 25 



through accidental 



conditions, 25 



natural resistance 

 against, 49 



of various diseases, rel- 

 ative susceptibil- 

 ity of man and 

 animals to, 52 



protective action of 

 blood serum 

 against, 50 



protective action of leu- 

 kocytes against, 

 50 



protective action of tis- 

 sues against, 50 



ptomains and, 28 



ptomains as indirect 

 cause of, 31 



racial differences and, 



oD 



resistance of living cell 



to, 6 

 secondary abscesses in, 



secondary modifying fac- 

 tors in, 2 



selective lodgment of 

 bacteria in body 

 and, 40 



similar, produced by dif- 

 ferent bacteria, 23 



species resistance to, 51 



specificity of bacteria 

 and, 22 



susceptibility to, racial 

 differences in, 55 

 relative, 51 



variation in. of differ- 

 ent strains of 

 same bacteria, 15, 

 16 



variation in degree of, 

 in bacteria suc- 

 cessively passed 

 through animals, 

 16, 17 



