540 



INDEX OF SUBJECTS 



Pearce and Eisenbrey's 

 work on anaphy- 

 laxis, 368, 369 

 Persensitized cells, 180 

 Petterson's investigations 

 on therapeutic use 

 of leukocyte ex- 

 tracts, 308 



Pfaundler's thread reac- 

 tion in agglutina- 

 tion, 222. 223 

 Pfeiffer on causes of bac- 

 terial anaphylax- 

 is, 412 

 work of, on anaphylaxis, 



366 



"Pfeiffer phenomenon" in 

 active immuniza- 

 tion, 89 



in bacteriolysis, tech- 

 f, nique of, 138 et 



seq. 



Metchnikoff's view of 

 phagocytosis in 

 peritoneal exu- 

 date and, 302 

 Phagocytes 276 

 fixed, 276 

 macrophages, 277 

 microphages, 277 

 motile, 276 

 Phagocytosis, 272 



acquired immunity and, 



298 



a 1 e x i n extraction in, 

 from leukocytes 

 and lymphatic or- 

 gans, 304 et seq. 

 chemotaxis in, 285 

 influence of bacteria 



in, 288, 289 

 influence of bacterial 



extracts in, 288 

 malic acid in, 286 

 of slime-molds or myx- 



omycetes, 286 

 of spermatozoa of 



ferns, 286 

 Pfeffer's technique in, 



286 

 destruction of bacteria 



in, 297, 300 

 by alexin (or cytase) 

 in leukocytes, 

 301, 302 

 action of, 302 

 Metchnikoff's inter- 

 pretation of, 302 

 by exudates, 300 

 by phagocytes, 300 

 destruction of red blood 



cells by, 276 

 differences in degree of, 

 due to bacteria, 

 325 



differences in phagocytic 

 energy in, due to 

 leukocytes in, 324 

 differences in virulence 

 of bacteria, de- 

 pendent on their 

 resistance to leu- 

 kocytes in, 325 

 digestion among proto- 

 zoa and, 274 

 "dust cells" in, 279 

 early investigations in, 



272 

 endothelial cells in, 278, 



279 



enzymes in, endocellular 

 and extracellular, 

 305 

 eosinophile cells in, 278 



Phagocytosis, fixateur or 

 sensitizer in, ac- 

 tion of, in im- 

 munized animals, 

 301 



giant cells in, 280 

 foreign body, 280 

 tuberculous, 280 

 in daphnia, 296 

 in higher animals, 296 

 in immune serum, 315 

 bacteriolysins in, bac- 

 tericidal sensitiz- 

 ers and, 321 et 

 seq. 



heated, opsonic action 



in, increase of, by 



addition of fresh 



normal serum, 318 



increase of, 311 



attributed to "stim- 



ulins," 311 

 with addition of 



leukocytes, 312 

 opsonin contents a 



factor in, 313 

 opsonins in, increase 



of, 315 

 normal opsonins 



and, 320 et seq. 

 specificity of, 321 

 thermostability of, 



320 



in immunity, 90 

 in normal serum, op- 

 sonins in, cooper- 

 ation of h e a t- 

 sensitive body in, 

 319 



nature of, 316 

 similarity of, to 



alexin, 316, 317 

 specific thermosta- 

 ble, 317 



specificity of. 318 

 in process of inflamma- 

 tion, 280 et seq. 

 with pyogenic staphy- 



lococci. 281 

 with tubercle bacilli, 



283 



increase of, by injection 

 of leukocyte ex- 

 tracts, 308 et seq. 

 in increased resist- 

 ance, 329 

 with acquisition of 



immunity, 299 

 intracellular digestion 



and, 274 



in vertebrates, 275 

 leukocytes in, 324 

 action of. 275, 276 

 polynuclear, 278 

 leukocytosis in, 290 

 bacteria decreasing, 



290 

 bacteria increasing, 



290 

 lymphocytes in, large, 



278 



measure of degree of, in 

 active immuniza- 

 tion, 329 

 Leishmann's technique 



for, 329 



Simon, Lamar and 

 Bispham's tech- 

 nique for, 332, 

 333 

 value of, in therapeu- 



sis, 338 



Wright's technique 

 for, 330 et seq. 



Phagocytosis, measure 

 of degree of, 

 Wright's tech- 

 nique for. diffi- 

 culties in. 332, 333 

 value of, 333 



mechanism of process of, 

 280 et seq. 



Metchnikoff's early in- 

 vestigations o n, 

 273, 274 



normal and immune op- 

 sonic action in, 

 quantitative dif- 

 ferences between, 

 324 



normal degenerative and 

 retrogressive proc- 

 esses and, 276 



observation of. in vitro, 

 313 



of micro-organisms, with 

 or without cul- 

 ture media, 297 



opsonins in. See Op- 

 sonins 



phagocytes engaged in, 



varieties of, 276 

 fixed, 276 

 macrophages, 277 

 microphages, 277 

 motile, 276 



process of inflammation 

 in, 280 et seq. 



proteolytic enzymes from 

 leukocytes in, 306, 

 307 



qualitative difference be- 

 tween normal and 

 immune opsonic 

 substances in, 315, 

 316 



reduction of phagocytic 



activity in, 298 

 by growth of bacteria 

 within leukocytes, 

 298 



by protection of bac- 

 teria from pha- 

 gocytes, 299 

 by use of narcotics, 

 299 



relation of, to active im- 

 munity, 329 



relation of virulence to, 

 312 



removal of extravasa- 

 tions of blood 

 and, 275 



resistance of bacteria 

 to, due to non- 

 absorption of op- 

 sonin, 326 



resistance of infected 

 subject and, 296, 

 297 



resistance of virulent 

 bacteria to, in 

 normal serum, 325 



spontaneous, 313 



tissue cells in, 278 



varieties of body cells 



engaged in, 278 

 dependent on nature 

 of invading sub- 

 stance, 279 



Pick and Yamanouchi's ex- 

 periments on two 

 separate sub- 

 stances in ana- 

 phylactic antigen, 

 388 



work on anaphylaxis, 

 371 



