INDEX OF SUBJECTS 



543 



Serum, normal, opsonins 

 in, resistance of, 

 to heat, 315 

 similarity of. to 



alexin, 316, 317 

 specificity of, 318 

 thermostability of, 



320 

 specific thermostable 



opsonins in, 317 

 normal antitoxic, diph- 

 theria, 107 



opsonins in normal and 

 immune, qualita- 

 tive differences in, 

 315, 316 

 Serum sickness, 426 



analogy of anaphylaxis 



with, 428 

 antibody formation in, 



429 

 incubation time in, 



429 



methods of administra- 

 tion of antitoxin 

 to avoid, 430 

 Besredka's method of, 



431 

 by alteration of serum, 



430 

 Friedberger andMita's 



method of, 432 

 in animal experimen- 

 tation, 431 



with concentrated an- 

 titoxin, 430 



von Pirquet and Schick's 

 studies of, 427 et 

 seg. 

 symptoms of, 426 



accelerated reaction of 

 von Pirquet and 

 Schick in, 427 

 after first injection, 



426 

 after second injection, 



427 

 immediate reaction in, 



427 



analogy of, to ana- 

 phylaxis, 427 



Serum therapy, anaphylax- 

 is in. See Serum 

 sickness 



in diphtheria, 446. See 

 also Diphtheria 

 antitoxin 



in diseases caused by 

 bacteria which do 

 not form soluble 

 toxins, 466 



action of serum upon 

 extensive infec- 

 tion in, 467 

 antibacterial action in, 



466 



in epidemic cerebrospinal 

 meningitis, 469. 

 See also under 

 C e r e b r o spinal 

 meningitis, epi- 

 demic 



in plague, 478. See also 

 Plague, serum 

 therapy of 



in pneumonia, 474. See 

 also Pneumonia, 

 serum therapy 

 in 



In streptococcus infec- 

 tions, 471. See 

 also under Strep- 

 tococcus infec- 

 tions 



Serum therapy, in typhoid 

 fever, 475. See 

 also Typhoid 

 fever, serum ther- 

 apy of 



Side chain theory, anti- 

 body production 

 in body cells in, 

 130 

 body cell in, 125 



chemical nature of, 



126 

 "Leistungskern" in, 



126 



side chains or recep- 

 tors in, 126 



chemical action of anti- 

 gens in, 128 

 definition of side chains 



in, 126 



diagram showing cell- 

 receptors and im- 

 mune bodies (Ehr- 

 lich) in, 127 

 in toxin-antitoxin reac- 

 tion, 124 



overproduction of recep- 

 tors in, 129 

 flow of, into blood a 

 cause of immu- 

 nity, 128 

 physical mechanism of, 



124 



recapitulation of, 130 

 relationship between 

 susceptibility p f 

 tissue and toxin- 

 binding properties 

 in, 131 



Skin, defence of, in infec- 

 tion, 12 



Skin infections, local im- 

 munity in, 102 

 Small-pox, active prophy- 

 lactic immuniza- 

 tion against, 

 488 

 Jenner's discovery of, 



488 



production and prep- 

 aration of vac- 

 cine for, 488 

 history of experimenta- 

 tion in immuniza- 

 tion against, by 

 Jenner, 62 



relative susceptibility of 

 man and animals 

 to, 54 

 vaccination for, history 



of, 62 



principles of, 62 

 Smith, Theobald, investiga- 

 tions of, in ana- 

 phylaxis, 363 

 phenomenon of, in ana- 

 phylaxis, 361 

 Snake venoms, 36 

 action of. 465 

 activation of, by endo- 

 complement in 

 blood cells, 174 

 by sera, 174 

 antitoxins for, 464 



effect of heat on, 105 

 immunization against, 



464 

 Kyes' experiments in, 



174, 175 



neurotoxins in, 465 

 peculiarities of, 464 

 toxin-antitoxin combina- 

 tion in, stability 

 of. 105 



Snake venoms, toxin-HCl 



modification ' of, 



effect of heat on, 



106 



toxin-antitoxin reaction 



with, 105, 465 

 filtration experiments 



in, 105 

 neutralization theory 



of, 105 

 time element in, 



105 



Sols, 500 



Species resistance, 51 

 Specificity, definition of, 76 

 Spermatotoxins, 92 

 Spleen, removal of, and 

 antibody - forma- 

 tion in active im- 

 munity, 100 

 and susceptibility to 



infection, 101 

 Standardization of anti- 

 toxin, guinea pigs 

 used in, 108 

 minimum lethal dose in, 



109 



Standardization of diph- 

 theria antitoxin, 

 by means of tox- 

 in, 107 



early attempts at, 107 

 unit in, 107 



Standardization of sera, 

 Pfeiffer's method 

 of, 139 



Standardization of tetanus 

 antitoxin by 

 means of toxin, 

 107 



Standardization of vac- 

 cines, 352 

 Hopkins' method of, 



353 

 Wright's method of, 352, 



353 



Staphylococcus furunculo- 

 sis, opsonic index 

 in vaccine treat- 

 ment of, 335 



Staphylococcus infections, 

 opsonic index in, 

 334 



during vaccine treat- 

 ment with dead 

 s t a p h ylococcus 

 cultures, 335 

 relative susceptibility of 

 man and animals 

 to, 54 



Stern's modification o f 

 Wassermann test, 

 209 



Stimulins, 311 

 Strauss test, 25 

 Streptococci, variations in, 



472 



Streptococcus infections, 

 agglutination re- 

 action in diag- 

 nosis of, 222 

 relative, of man and 



animals, 54 

 serum therapy in, 471 

 difliculties in, owing 

 to variations of 

 streptococci, 471, 

 472 

 early investigations in, 



472 

 Marmorek's work on, 



472, 473 



nature of action in, 

 473 



