544 



INDEX OF SUBJECTS 



Streptococcus infections, 

 serum therapy in, 

 standardization of 

 serum in, 474 

 value of. 473 



Strong's investigations in 

 prophylactic im- 

 munization 

 against plague, 

 487 



method of prophylactic 

 vaccination i n 

 cholera, 486 

 Sub-infection, 24 

 "Summation of negative 

 phase" in active 

 i m m u n i zation 

 338, 339 



"Summation of positive 



phase" in active 



immunization, 339 



Surface tension in chemo- 



taxis, 293 



Susceptibility, body tem- 

 perature and, 51 

 cultural conditions for 

 bacteria in body 

 and, 56 



increased invasive pow- 

 ers of bacteria 

 and, 56 

 individual differences 



and, 58 

 inheritance a factor in, 



56 



racial differences in, 55 

 relative, of animals to 



infection, 51 

 species resistance to in- 

 fection and, 51 

 Sycosis, opsonic index in 

 vaccine treatment 

 of, 336, 337 

 Syntoxoids, 116 

 Syphilis, diagnosis of, 

 B o r d e t-Gengou 

 phenomenon in, 

 188 

 by a 1 e x i n fixation, 



198, 199 



by direct precipita- 

 tion of syphilitic 

 serum by emul- 

 sions of lecithin 

 and of sodium 

 glycocholate, 204 

 relative susceptibility of 

 man and animals 

 to, 52 



ultramicroscopic method 

 of finding precipi- 

 tates in sera of, 

 204 



Wassermann reaction in, 

 diagnostic value 

 of, 210, 211 

 technique of, 207 

 Bauer's modification 



of, 209 



Noguchi's modifica- 

 tion of, 208.209 

 schematic presen- 

 tation of, 209 

 Stern's modification 

 of, 209 



Temperature, body, and re- 

 sistance to infec- 

 tion. 51 



Tetanus, "cryptogenic," 5 

 relative susceptibility of 

 man and animals 

 to, 53 



Tetanus, toxin fixation in, 

 by brain tissues, 

 131 

 lipoidal, substances 



a factor in, 133 

 proteolytic enzymes 



a factor in, 133 

 temperature a fac- 

 tor in, 132 



Tetanus antitoxin, produc- 

 tion of, 463 

 standardization of. 463 

 by means of toxin, 107 

 Tetanus bacillus, action of, 



4, 5 

 Tetanus toxin, action of, 



41 



Thread reaction of Pfaund- 

 ler in agglutina- 

 tion, 222, 223 

 Thymotoxin, 92 

 Thyroid gland, production 



of alexin in, 172 

 production of opsonins 



in, 173 

 Toxemia, 10 



Toxicity, definition of, 11 

 Toxin-antitoxin, diphthe- 

 ria. See Diph- 

 theria toxin-anti- 

 toxin 



Toxin-antitoxin combina- 

 tion, chemical re- 

 lations of, 114 

 effect of heat on, 106 

 in snake venom, stabil- 

 ity of, 105 

 toxin-HCl modification 



of, 106 

 effect of heat on, 



106 



measurement of, by par- 

 tial absorption 

 method of Ehr- 

 lich, 115 

 stability of, 105 

 valency of component 



parts of, 114 



Toxin-antitoxin reaction, 

 analogy between 

 chemical reac- 

 tions and, 118, 

 119 



antibody production in 

 body cells in, 130 

 body cell in, 125 



chemical nature of, 



126 



chemical action of anti- 

 gens in, 128 

 concentration of reagents 



in, 107 

 degrees of toxicity in, 



123 



direct neutralization the 

 protective power 

 of, 124 



effect of heat on, 105 

 effect of temperature on, 



104 



mechanism of, 104 

 neutralization in, absorp- 

 tion theory of, 

 123 

 Arrhenius and Madsen 



on, 120 

 Bordet on, 122 

 Bordet - Danysz phe- 

 nomenon in, 123 

 von Dungern's views 



on, 124 



Danysz effect in, 123 

 phenomena of, 119 et 

 seq. 



Toxin-antitoxin reaction, 

 overproduction of 

 receptors in, 128 

 flow of. into blood a 

 cause of immu- 

 nity, 128 

 physical mechanism of, 



124 

 quantitative relations in, 



106, 123 



relationship between sus- 

 ceptibility of tis- 

 sue and toxin- 

 binding properties 

 in, 131 

 side chain theory in, 



124 



specificity of, 124, 129 

 speed of action of, 107 

 time element in, 105 

 with snake venom, 105 

 filtration experiments 



in, 105 

 neutralization theory 



of, 105 



time element in, 105 

 Toxin, bacterial. See Bac- 

 terial toxins, 

 chemical relations of, 

 with antitoxin, 

 114 

 deterioration theory of, 



110 



definition of, 32 

 differences in combining 



avidity of, 111 

 diphtheria, construction 



of, 118 

 normal, 107 

 direct effect of antitoxic 



serum on. 104 

 epitoxoid form of, 112 

 indirect effect of anti- 

 toxic serum on, 

 104 



structure of, 110 

 toxoid, 110 



prototoxoids in, 115 

 syntoxoids in, 116 

 toxon, 113 

 true, 33 



analogy of, with en- 

 zymes, 36 



bacteria producing, 34 

 characteristics of, 34 

 chemically indefinable 



nature of, 35 

 diseases for which 

 some investigators 

 claim, 469 

 heat sensitiveness of, 



36 



incubation time of, 36 

 production of anti- 

 toxin by, 35 



Toxin hypersusceptibility, 

 anaphylaxis and, 

 407 



Toxin spectra, construc- 

 tion of, 116 

 definition of, 116 

 measurement o f, 116, 



117 



principles of, 116 

 Toxin unit, definition of, 



109 



diphtheria, 107 

 Toxoids, definition of, 110 

 Toxons, action of, 113 

 definition of, 113 

 structure of, 113 

 Toxophore group of toxin, 



110 

 action of, 110 



