512 



INDEX 



Colloids, physical proper- 

 ties of, size of 

 particles in, mi- 

 croscopic, 547 

 osmotic pressure in, 



547 

 rate of settlement 



in, 548 



ultraflltration meth- 

 od in, 548 

 surface tension in, 550 



et seq. 

 preparation of solutions 



of, 558, 559 



reaction in, analogous to 

 complement devi- 

 ation phenomenon 

 of Neisser-Wechs- 

 berg, 162 

 inhibition zones in, 



102 



reversible, 544 

 sol, 544 



stability of, 545 

 suspension, 544, 554 

 Complement. See also 



Alexin 



amboceptpr and, Xogu- 

 chi's measurement 

 of quantitative 

 relations of, 

 104 



quantitative ratio be- 

 tween. 1(53. 104 

 union of, Khrlich and 

 Sachs's views on, 

 104, 1(55 

 definition of, 144 



in hemolysis, 144 

 multiplicity of, 154 et 



scq. 

 Borders views on, 



156 

 Ehrlich's views on, 



155 

 nature of, 154 



chemical. 174 

 Complement deviation, 160 



et seq. 



argument in favor of 

 Bordet's v i e w s, 

 162, 163 



colloid reactions, analo- 

 gous to, 1(52 

 Gay's explanation of, 



163 

 in hemolytic reactions. 



163 



Morgenroth and Sachs's 

 experiments sup- 

 porting. 163 



pro-agglutinoid zone re- 

 action analogous 

 to. 162 



Complement fixation, 180. 

 <SYe also Alexin 

 fixation 



in determination of na- 

 ture of unknown 

 protein. 211 

 delicacy of, 212, 



213 



technique of. 212 

 practical applications of, 



198 

 test of. in diagnosis of 



glanders, 216 

 in diagnosis of gonor- 

 rhea! infections, 

 216 



in diagnosis of malig- 

 nant neoplasms, 

 213 



Complement fixation, test 

 of, in diagnosis of 

 malignant n e o - 

 plasms, von Dun- 

 gern's method of, 

 214 



antigen produc- 

 tion for, 214 

 results of, 215 

 technique of, 214 



et seq. 



in diagnosis of syphi- 

 lis, 512 



in diagnosis of tuber- 

 culosis, 217 



Complement splitting, 178. 

 See also under 

 Alexin, splitting 

 of 



Complementoid, 158 



Complementophile group 

 of amboceptor, 

 149 



Couglutinin, 167 



Conjunctiva, susceptibility 

 of, to infection, 

 13 



Corpus luteum cytotoxin, 

 92 



"Cryptogenic tetanus," 5 



Cultivation of bacteria, ar- 

 tificial, 10 



Cytases, in phagocytes, de- 

 struction of bac- 

 t e r i a by, 301, 

 302 



Cytolysius, 92 



Cytolysis, 134 



Cytolytic substances, ori- 

 gin of, from leu- 

 kocytes, 169 et 

 seq. 



Cytophile group of ambo- 

 ceptor, 149, 152, 

 153 



Cytotoxins, 92 

 specificity of, 92 



Danysz effect in neutral- 

 ization in toxin- 

 antitoxin reac- 

 tion, 123 



Danysz toxin-antitoxin 

 phenomenon, ap- 

 plication of col- 

 loid phenomena 

 to, 561 



D a p h n i a. Metchnikoff's 

 study of. 274. 296 

 phagocytosis in. 29(5 



Dean's antiplague sera, 

 482 



Denys and Leclef on im- 

 portance of phag- 

 ocytosis in im- 

 munity. 311, 312 



Diphtheria, active immu- 

 nization in. with 

 toxin - antitoxin, 

 4(50 



relative susceptibility of 

 man and animals 

 to, 53 



Diphtheria antitoxic ser- 

 um, normal, 107 



Diphtheria antitoxin, 448 

 antitoxin production in, 



457 



concentration of. 459 

 presence of, in blood of 

 normal individ- 

 uals, 450 



Diphtheria antitoxin, pre- 

 servation of, 108 

 speed in administration 



of, 449 

 speed in absorption of, 



451 



on intravenous injec- 

 tion, 451, 452 

 on subcutaneous in- 

 jection, 451, 452 

 speed of diagnosis for, 

 necessity of, 4oo 

 stability of, 108 

 standardization of, 457 

 by means of toxin. 



107 



early attempts in, 107 

 statistics showing reduc- 

 tion of mortality 

 with, 448 



toxin production for, 454 

 choice of culture in, 



454 

 cultivation of strain 



in, 454, 455 

 culture medium in, 



455 

 "maturing" of toxin 



in, 455 

 testing of toxin in, 



456 

 Theobald Smith's 



method of, 456 

 unit of, 107 

 Diphtheria bacillus, action 



of, 4, 5 

 Diphtheria toxin, action 



of, 41 



construction of, 118 

 determination of diph- 

 theria immunity 

 with, 464 

 normal, 107 

 stability of, 108 

 unit of,' 107 



Diphtheria toxin-antitoxin, 

 neutral mixtures 

 of, 460 



Behring's method of im- 

 munization with, 

 400 



advantage's of, 461 

 chief value of. 461 

 danger of anaphylaxis 



in, 401 



determination of pres- 

 ence of free tox- 

 in o* antitoxin in 

 convalescents fol- 

 lowing treatment 

 with. 464 

 human susceptibility to. 



461 



production of homolo 

 gous antitoxin in 

 h u in a n beings 

 with, for passive 

 i in in u n i zation, 

 462 

 results of treatment 



with, 462 



standardization of anti- 

 toxin. 462. 463 

 limes-necrosis of toxin 



in. 403 

 Itomer's method of, 



403 



toxic action of, 400 

 Doerr and Kuss's experi- 

 ments on two sep- 

 arate substances 

 in anaphylactic 

 antigen, 389 



