INDEX 



575 



Immunity, natural, mecha- 

 nism of, theories 

 concerning, phag- 

 ocytic activities 

 of blood, 79 

 phagocvtic activities 



of'blood in, 79 

 principles of, 50 



body temperature 



in, 51 



cultural conditions 

 for bacteria in 

 body a factor in, 

 56 



increased invasive 

 powers of bac- 

 teria in, 56 

 individual differ- 

 ences in, 58 

 inheritance in, 56 

 racial differences in, 



55 



relative resistance 



of animals in, 51 



species resistance 



in, 51 

 Pfeififer phenomenon in, 



138 



phagocytosis in, 90 

 Immunization, 60 



against snake venoms, 



466 



history of, 61 



Immunization, active. See 

 also Vaccine ther- 

 apy 



against anthrax, 64 

 against chicken cholera, 



63 



against small-pox, 62 

 agglutination of bacteria 



in, 89 

 "alkalinity theory" of, 



83, 84 



antibacterial, 85, 87 

 antibodies in, 85 



bodies in. fundamen- 

 tal principles of 

 theory of, 84 

 origin of, 100 

 antitoxic, 85 

 as a therapeutic meas- 

 ure, action of. in 

 generalized sys- 

 temic infections, 

 347 

 in local infections, 



346 

 in successive local 



infections, 347 

 value of, 346 



in acute diseases, 



350 



in subacute or 



chronic cases. 349 



as prophylactic measure. 



value of, 345, 346 



autogenous vaccines in, 



351 



auto-inoculation by mas- 

 sage in. 340 

 bacteria used in, 85, 87- 



89 



bacteriolysins in. 89 

 by mean's of living but 

 attenuated cul- 

 tures. 65 



concentration of anti- 

 bodies in lym- 

 phatic organs in, 

 101 



in other organs in, 

 102 



Immunization, active, defi- 



nition of, 63 

 "exhaustion theory" of, 



83 

 "high tide" of immunity 



in. 340 

 in diphtheria, with tox- 



in-antitoxin mix- 



tures, 460. See 



also Diphtheria 



toxin-antitoxin 

 invasion of bacteria in, 



mechanism of re- 



action in tissue 



cells against, 103 

 locality of production of 



antibodies depen- 



dent on locality 



of antigen con- 



centration in, 



102 



negative phase in, 338 

 second injection in, 



338 

 successive inoculations 



in, 338, 339 

 summation of, 338 



339 

 non-bacterial anti-toxin- 



stimulating sub- 



stances in. 86, 87 

 "osmotic theory" of, 84 

 phagocytosis in, 90 

 phenomena following, 82 

 precipitin formation in, 



90 

 reaction of tissue cells 



to invasion in, 



103 

 removal of spleen in. 



and antibody-for- 



mation. 101 



"retention theory" of. 83 

 second positive phase 



in. 339 

 specificity of antibodies 



in. 85 

 summation of positive 



phase in. 339 

 tuberculins in. 355 

 vaccines in. 351 

 production of. 351 

 sensitized. 355 

 with dead bacteria, 



351 

 with living bacteria, 



351 

 standardization o f, 



353 

 Hopkins' method of. 



353 

 Wright's method of, 



352. 353 

 with antigens, analogy 



between drug tol- 



erance and. 99 

 with bacterial extracts, 



69 

 extraction of bacteria 



for, by mechan- 



ical methods. 71 

 by permitting them 



to remain in fluid 



media. 70 

 with bacterial products, 



72 



with dead bacteria, 68 

 methods used in kill- 



ing bacteria for, 



ing 



68 



with fully virulent cul- 

 tures in sublethal 

 amounts. 66-68 



Immunization, active, with 

 sensitized b a c - 

 teria, 68 



Immunization, active pro- 

 phylactic, in man, 

 483 



against cholera, 487. See 

 also under Cholera 



against paratyphoid 

 fever. 484 



against plague, 487. See 

 also under Plague 



against poliomyelitis, 

 495 



against rabies, 492. See 

 also under Rabies 



against small-pox, 490. 

 See also under 

 Small-pox 



against syphilis, 498 



against typhoid fever, 

 484. See also 

 under Typhoid fe- 

 ver 

 Immunization, passive, 74 



antitoxins in, 86 



definition of. 64 



history of. 74 



in diphtheria. See Diph- 

 theria antitoxin 



in diseases caused by 

 bacteria which do 

 not form soluble 

 toxins. 468. See 

 also under Serum 

 therapy 



therapeutic application 

 of. 75 



toxin-antitoxin reaction 

 in. 104 



underlying principles of. 



75 



Immunized animals, bac- 



' teriolysis in, 137 



summary of facts in, 



138 



Incubation of bacteria. 26 

 Infection, acquired resis- 

 tance to, 60 



adaptation of bacteria 

 in tissues in. 6, 7 



aggressin secretion of 

 bacteria in body 

 and. 20-22 



body temperature and. 51 



capsule formation of 

 bacteria and. IN 



chronic, adaptation of 

 bacteria in, 8 



clinical manifestations 

 of, 28 



conjunctiva susceptible 

 to, 13 



criteria governing. 3 



cultural conditions for 

 bacteria in body 

 and. 56 



defense of intestinal 

 tract in, 12 



defense of mucous mem- 

 branes in. 12. 13 



defense of skin in, 12 



definition of. 5. 6 



different, produced by 

 same bacteria 23 



effect of body tempera- 

 ture on invasive 

 powers of bac- 

 teria in. 2 



effect of cultural adap- 

 tability of bac- 

 teria on, virulence 

 of, 12 



