. 



CONTENTS 



Amniota . 



Reptilia ..... .112 



Aves .... 112 



Manunalia 



Accessory adrenal bodies . 114 



Accessory cortical bodies . . ll(i 



Accessory " medullary " bodies (chromaphil 

 bodies) .... .116 



r. Tabular statement of chief facts in the comparative 



anatomy of the adrenal bodies . .126 



C. Development of the adrenal bodies. 



D. Addison's disease and the pathology of the adrenal bodies. 



1. Introductory and historical 



2. Symptoms 



(1) Pigmentation 



(2) Asthenia . . .129 



(3) Other symptoms . 130 

 The " white line " of Sergent 



3. ^Etiology and onset . . 



4. Metabolism in Addison's disease 



5. Morbid anatomy of Addison's disease 



6. Pathogeny of Addison's disease . .134 



7. Course and event of the disease diagnosis, prognosis, 



and treatment ... ... 137 



8. Other conditions involving adrenal insufficiency . .138 



9. Excessive adrenal function . . . . .138 

 10. Adrenal tumours ... . 139 



A. Tumours of the adrenal medulla (chromaphil 



tissue) . ... 139 



B. Tumours of the adrenal cortex . . .140 



E. Extirpation experiments in mammals . . .140 



F. The question as to accessory adrenal bodies in relation to extir- 



pation experiments in mammals . . . . .147 



G. Extirpation of the adrenal bodies in the lower vertebrata . .149 

 H. The question as to the relative importance to life of cortex and 



medulla .... ..... 152 



I. Changes found post-mortem after extirpation of the adrenal 



bodies .......... 154 



J. Compensatory hypertrophy of the adrenal bodies . . .154 

 K. Transplantation of the adrenal bodies . . . . .156 



L. The pharmacodynamics of extracts of adrenal medulla (chroma- 



phil tissues) and of adrenin . . . . . .158 



1. The general physiological effects of chromaphil tissue 



acts and adrenin ...... 158 



2. The special physiological effects of chromaphil tissue 



extracts and of adrenin . . . . .165 



(1) The effects upon the heart and arteries . . 165 



(2) The effects on other structures, and the mode 



and seat of action of adrenin . . .177 

 M. The chemical nature of the active substance of the adrenal 



ilia and otli-r rlin.maphil tissues . .... 185 



rnal secretion of adn-niii . . . . .199 



N. The origin of adrenin in the body ...... 200 



MC mode of disposal of adrenin in the body . . . L'ol 



