CONTENTS 



CHAPTER I 



PAGES 



J INTRODUCTORY SECRETION AND INTERNAL SECRETION . . 1 11 



Definition of secretion . . . . . . ... 1 



Ductless glands . . . . . .,',-* . 4 



Internal secretion . . . . . .... 5 



Organo- therapy ......... 6 



Nature of internal secretion . . . . . . . 7 



Limitation of the term "internal secretion" . . . .9 



Internal secretion and pathology ...... 9 



CHAPTER II 



DEFINITION AND LIMITATION OF THE TERM " INTERNAL SECRETION " 12 19 



" Negative internal secretion " . . . . . .16 



" Hormones " . .16 



CHAPTER III 



GENERAL METHODS OF INVESTIGATION AND THE VALUE OF THE RESULTS 



WHICH MAY BE OBTAINED BY SUCH METHODS . . 20 34 



Pathological methods ........ 20 



Experimental pathology . . . . . . . .21 



Extirpation experiments . . . . . . . .21 



Grafting 22 



Feeding 22 



Subcutaneous injections ........ 22 



Intravenous injections . . . . . . .22 



Depressor substances ........ 25 



Pressor substances ......... 25 



Observations upon frog's mesentery . . . . . .31 



Cytotoxic sera ...... . . 33 



" Vividiftusion " 33 



CHAPTER IV 



J THE NATURE, MODE OF ACTION, AND ORIGIN OF HORMONES . 35 37 

 Augmentory and inhibitory hormones ... .35 



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