156 THE DUCTLESS GLANDS 



piecemeal extirpation a gland was successfully removed ; the 

 medulla of the gland left behind grew, and the cortex apparently 

 not. But in a rabbit both cortex and medulla grew. This 

 does not accord with the observations of Poll and Vassale. - 

 From some experiments carried out in my laboratory, I am 

 inclined to believe that in dogs, after a large part of the ad- 

 renals have been extirpated, there is a notable compensatory 

 hypertrophy of the abdominal chromaphil body. 



K. Transplantation of the Adrenals 



Although considerable attention has been devoted to the 

 subject of transplantation of the thyroid, comparatively little 

 has been done in this direction with the adrenal bodies. 



Canalis appears to be the earliest worker who attempted 

 adrenal transplantation. He grafted small portions of the 

 adrenal into the kidney, but they became necrotic and were 

 absorbed. Only once, fifteen days after the operation, did he 

 find in the kidney scar the capsule of the adrenal and some of 

 the cells of the external layer of the cortex. 



Boinet transplanted adrenals intraperitoneally into rats. 

 He observed atrophy and absorption, which, however, was 

 sometimes delayed. He noted red spots on the transplanted 

 organs, which he called " hemorrhagies capsulaires." 



Gourfein reports that six days after the transplantation of 

 frog's adrenal into the lymph sac of another frog the organ 

 became decolorized, and attached by connective tissue to the 

 muscles. After twenty days the decolorization and adhesions 

 were more marked, and after forty days the gland was absorbed. 

 When the adrenals of a guinea-pig were transplanted into the 

 lymph sac of a frog there were adhesions, leucocytal infiltration 

 of the gland, and inflammation of the surrounding tissue. 



In all these experiments the effect was no more than that of 

 the administration of a certain amount of adrenal substance 

 in the form of the gland itself. The effects, if any, were purely 

 chemical. 



Poll was the first to make a systematic macroscopic and 

 microscopic investigation of the transplanted gland. This 

 author employed rats for his experiments. He removed the 

 left adrenal body from behind, and in one series of experiments 

 transplanted it into the doisal muscles, in another series 





