THE ADRENAL BODIES 161 



striking symptom in dogs. There is abundant micturition, 

 but no hsematuria. 



In cats by far the most noticeable result of the injection 

 was an enormously increased rapidity of the respiratory 

 movements in the early stage. Thirst and loss of appetite 

 were recorded, but the paralysis was not so definite as in other 

 animals. In the cat doses sufficient to kill do not raise the 

 blood-pressure within half an hour of injection beneath the 

 skin. 



The remote effects noted by Foa and Pellacani, as well as 

 by Oliver and Schafer, were not noticed in this series of experi- 

 ments. If the dose were sufficiently large to produce any 

 effects at all, there were some changes in reaction and disposi- 

 tion within a few minutes. 



After it had been shown by experimental evidence (Vincent) 

 that the "paired suprarenal bodies " ("medullary " or " chroma - 

 phil bodies ") and the inter-renal gland of Elasmobranch fishes 

 correspond respectively to the medulla and the cortex of the 

 adrenal body of the higher vertebrata, and that the " cor- 

 puscles of Stannius " of Teleostei consist solely of " cortical " 

 substance, it appeared to be a matter of some interest to test 

 the effects of the two kinds of tissue in Elasmobranchs and of 

 the cortical bodies of Teleosts when extracts of them are 

 injected subcutaneously into small animals. Naturally, only 

 very small quantities of material could be obtained for this 

 purpose, but tfie effects upon mice were quite definite. The 

 " corpuscles of Stannius " obtained from six specimens of the 

 codfish (Gadus morrJiua) were found to weigh in a moist state 

 0*4 gramme. These were extracted by boiling with a normal 

 saline solution. The filtered extract was then injected beneath 

 the skin of the back of a mouse. No effects whatever super- 

 vened. Next, the " paired suprarenals " of Balfour (" chroma- 

 phil bodies ") from seven specimens of Scyllium canicula were 

 found to weigh, when moist, 0*3 gramme. These were simi- 

 larly extracted, and the filtrate administered to the same 

 mouse (which had remained in perfect health) a few days later. 

 The animal was immediately and powerfully affected. The 

 breathing became very rapid, the limbs became weak, the 

 temperature lowered, and death with convulsions ensued in 

 less than five minutes. Extracts of the elasmobranch inter- 

 renal gland produced no effects when injected in the same 



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