164 THE DUCTLESS GLANDS 



substance which influences directly or indirectly the supply 

 of sugar in the organism. Biedl and Offer find that in this 

 form of diabetes also the pupil reacts to adrenalin dropped on 

 the conjunctiva. They further find that admixture with 

 lymph or simultaneous injection of lymph from another animal 

 prevents both the adrenin diabetes and the mydriatic reaction. 

 In this relation Schafer recalls the observation of Lepine that 

 in pancreatic diabetes the injection of lymph from a normal 

 animal produces marked temporary diminution of sugar in 

 the urine. He suggests that the lymph normally contains a 

 chemical (glycolytic ?) substance, derived from the islets of the 

 pancreas, which substance is essential to the due maintenance 

 of normal carbohydrate metabolism. This whole question has 

 recently been complicated by Pfluger's announcement of a 

 " duodenal diabetes " (vide supra, p. 40). It seems possible 

 that the final solution of the problem may be arrived at by 

 an accurate knowledge of the interaction between the adrenals 

 and the pancreas through the mediation of the sympathetic 

 nervous system. 



Meltzer found that subcutaneous injections of adrenalin, 

 which normally are without effect on the pupil, produce marked 

 dilation after removal of the superior cervical ganglion. 



Underbill and Closson could not find any change in the 

 nitrogen of the urine in adrenin glycosuria, such as was recorded 

 by Paton. 



It is stated that heat polypncea hinders the onset of adrenin 

 glycosuria, while warmth alone does not. This result appears 

 to depend on the destruction of the adrenin by the increased 

 chemical processes of the body, due to the polypnoea. 



Drummond reports that after administration of adrenalin 

 there occur congestion of organs and histological changes, 

 indicating that the substance acts as a protoplasmic poison. 



Oliver and Schafer suggested that the material obtained 

 from the adrenal medulla, which produces death, is of a different 

 nature from that which has such a powerful effect upon the 

 blood-pressure. The paralysis is due to the action of the 

 poison upon the central nervous system. The present writer 

 came to the conclusion that the adrenal body contains an 

 active principle which acts both centrally and peripherally. 

 The central action is produced most probably upon the mutm- 

 centres of the brain, while the peripheral action is shown by 



