226 THE DUCTLESS GLANDS 



prompted Pearlman and myself to a re-investigation of the 

 subject. We have performed a very large number of 

 experiments upon dogs, cats and rabbits. 



At the outset it was found that the conditions under which 

 the experiment is performed makes a very considerable differ- 

 ence in the character of the curve obtained by splanchnic 

 stimulation. There may also be differences characteristic of 

 the different species and of different conditions of the animal. 

 Anrep seems never to have obtained in his dogs under normal 

 conditions a form of curve which we now look upon as the 



FIG. 47. Dog, 12 K. Ether, vagi cut. Left splanchnic stimulated in thorax. 

 Time tracing in seconds. 



typical or normal, namely, a sharp rise (having a " hump " 

 about half-way up) followed by a marked " dip " nearly down 

 to the original level, and succeeded by a rise which lasts as 

 long as stimulation is continued (see Fig. 47). 



This occurs in dogs under ether with both vagi cut. Anrep 

 used A.C.E. mixture and morphine. Chloroform, curare, and 

 morphine sometimes modify the curve in such a way as to 

 abolish the " dip," leaving only the "hump" on the rise 

 (see Fig. 48). 



In many of our tracings the " hump " and the subsequent 

 "dip" are quite distinct (see Figs. 47, 48, 49) and the 



