THE PITUITARY 369 



Robertson states that he has succeeded in isolating from 

 the anterior lobe a substance called tethelin which quickens 

 growth in young animals and is thought to have a possible 

 value in hastening the healing process in wounds. 



M. The Comparative Physiology of the Pituitary Body 



Professor Osborne, working in conjunction with the present 

 writer, showed that extracts of the pituitary body of the cod 

 produce effects upon the heart and bloodvessels similar to 

 those of extracts of the mammalian posterior lobe. 



Schafer and Herring demonstrated that extracts made from 

 the cod's pituitary produce kidney dilatation and diuresis 

 when injected, just as do extracts from the mammalian posterior 

 lobe. 



The subject has been recently more thoroughly investigated 

 by Herring. This observer finds that the posterior lobe of the 

 pituitary body of the fowl produces an effect on blood-pressure, 

 kidney volume, and urine secretion, which is very similar to 

 that produced by extracts of the posterior lobe of the mam- 

 malian pituitary. It was found to be impossible to determine 

 whether the active principles in the posterior lobe of the bird's 

 pituitary are products of the epithelial cells of the pars inter- 

 media, or are formed solely in the nervous substance. No 

 distinct effects were produced by extracts of the avian anterior 

 lobe. 



In regard to Teleostean fishes, extracts of the anterior lobe 

 proper chromophil portion of Sterzi and Gentes have little 

 physiological effect. The general effect of extracts of the 

 posterior lobe is similar to that brought about by extracts of 

 the mammalian and avian posterior lobes. In Teleosts the 

 cells of the pars intermedia predominate in the posterior lobe, 

 and are inseparable from the pars nervosa, so that one cannot 

 determine which produces the active material. According to 

 Herring, both are probably concerned, for wherever cells of 

 pars intermedia chromophobe cells of Sterzi are bound up 

 with pars nervosa, extracts of the resulting tissue produce the 

 effects on blood-pressure, kidney volume, and urine secretion 

 which have been associated with extracts of the posterior lobe 

 of the mammalian pituitary. Extracts of the saccus vasculosus 

 are practically inactive, and Herring supports the supposition 



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