CONTENTS 



PART I. GENERAL. 



PAGE 



Historical and Introductory i 



Definition and Limitation of the term " Internal Secretion " 5 



Classification 8 



The Activity of the Hormones 12 



The Origin of the Hormones 15 



Sources of Information and Methods of Investigation ... 16 



PART II. SPECIAL. 



THE THYROID APPARATUS 26 



Anatomy ... ... ... ... ... ... ... ... 26 



Histology ... ... ... ... ... ... ... ... 26 



Chemistry 29 



Anatomy of the Parathyroid Glands 31 



Histology of the Parathyroid Glands ... ... ... 32 



History of the Development of the Organs of the Neck ... 33 



Comparative Anatomy of the Parathyroid Glands ... 34 



Physiology of the Thyroid Apparatus 36 



Historical ... ... ... ... ... ... ... ... 36 



Tetania Parathyropriva ... ... ... ... ... 39 



Tetany in Man 44 



Other Pathological Conditions in Man arising from 

 Derangement of the Function of the Parathyroid 



Glands 46 



The Therapeutics of Tetania Parathyropriva 47 



The Relationship between the Thyroid and Parathyroid Glands 51 



The Function of the Parathyroid Glands 55 



The Tetany Toxin 55 



The Parathyroid Glands and the Metabolism of Calcium 57 



The Point of Attack of the Hypothetical Tetany Toxin ... 50, 



Physiology of the Thyroid Gland 62 



Experimental Extirpation 62 



Athyrosis and Hyperthyrosis in Man 71 



Operative Athyrosis ... ... ... ... ... ... 71 



True Athyrosis and Hyperthyrosis ... 73 



Substitution Therapy 83 



The Metabolic Changes in Hypothyrosis and the manner 

 in which they are influenced by the Exhibition of 



Thyroid Extract 88 



The Physiological Effects of Thyroid Substances 89 



Experimental Hyperthyroidism 92 



Hyperthyroidism in Man 92 



As Produced by the Exhibition of Thyroid Gland ... 92 

 Conditions which may be classed as those of true Hyper- 

 thyroidism ... 93 



Theory of the Thyroid Function ... ... ... ... ... 104 



THE THYMUS GLAND no 



Involution of the Thymus ... ... ... ... ... 112 



Physiology of the Thymus 113 



Effects of Thymus Extract 121 



Mors Thymica and the Status Thymicolymphaticus ... 122 



