246 INTERNAL SECRETION 



be conceded that, upon the whole, the effect which different 

 physical conditions have upon the enlargement of the vessels as 

 induced by adrenalin, is at present insufficiently investigated. 



The influence which certain drugs have upon the changes in 

 the vessels produced by adrenalin, has formed the subject of 

 extensive investigation. Of these, iodine has received the most 

 attention. 



v. Koranyi found that the simultaneous exhibition of adren- 

 alin and iodine inhibits the changes which adrenalin provokes in 

 the vessels. Boveri arrived at the same conclusion, but Biland 

 obtained quite opposite results. He found that the simultaneous 

 exhibition of iodide of potassium and suprarenin favoured the 

 appearance of changes in the aorta. Hedinger, Loeb, and 

 Fleisher, as well as Kalamkarow, bring forward a large amount 

 of evidence in confirmation of Biland's findings; Klienenberger, 

 on the other hand, is unable to show that the effects of adrenalin 

 are inhibited by the action of iodine. The inhibitory influence of 

 iodipin upon the development of adrenalin sclerosis, depends 

 upon the amount of sesame oil which it contains (Schrank). 

 According to Mansfield, the simultaneous employment of cholin 

 with adrenalin does not arrest the changes in the vessel walls. 



The vast majority of authors who have occupied themselves 

 with the question of the changes which adrenalin produces in 

 the vessels, have discussed this condition in its relation to the 

 clinical form of arteriosclerosis. The views which different 

 authors hold upon this subject are, however, very diverse. Josue, 

 Loeper, Gouget, Gilbert and Lion, Boveri, Braun, etc., believe 

 that the two conditions are more or less identical ; while Fischer r 

 v. Rzentkowski, Scheidemandel, Hedinger, d'Amato, Lissauer, 

 Loeb, Klotz, Saltykow, etc., lay stress upon the differences which 

 subsist between the two conditions. Certain signs, such as the 

 calcification of the media as seen in the clinical condition, are 

 believed by many authors (v. Erb, Biland, Bennecke, Klotz, 

 Marchand, Saltykow, etc.) to be common to both pathological 

 forms. 



ADRENALIN AS A SECRETORY PRODUCE OF THE 

 ADRENAL SYSTEM. 



It has been shown that adrenalin is a well defined chemical 

 substance, minimal quantities of which produce definite physio- 

 logical results. The next step is to discover whether this sub- 

 stance is formed and passes into the circulation during life, or 

 whether it comes into existence post mortem. 



The first question to be decided, however^ is in which of the 

 two suprarenal systems is adrenalin formed ? As stated in an 

 earlier chapter, Vulpian and Virchow were able to obtain the 

 colour-reactions characteristic of adrenalin with the medullary 

 substance of the suprarenal only; with that tissue, in fact, which, 



