596 



INTERNAL SECRETION 



Hypophysis, nervous portion of struc- 

 ture of, 310 



, physiology of, 315-321 

 , relationship to gigantism, 341 



to sexual glands, 33Q-34I 

 to suprarenals, 339 



to thymus, 339 



to thyroid gland, 338 

 , sarcoma of, 334 

 , secretion of, histology of, 311 

 , sources ot origin, 315 

 , tumour of, extirpation of, in man, 



, in acromegaly, 306, 332, 333 



, obesity associated with, 345-347 

 , weight of, 307 



, see also Pituitary extract 

 Hypothyrosis, metabolic changes in, 

 88 



in children, 76, 77 

 Humoral pathology, 2 



and circulation of blood, 2 



INDICAN reaction in urine after re- 

 moval of suprarenal capsules, 



1 ?4 



Infantilism, 77 

 , dystrophic, 77 

 , following thyroidectomy, 64 

 , myxcedematous, 77 

 Infants, laryngeal spasm of, 122 

 - tetany in, 45 

 Infective diseases, mortality from, 



great among subjects of status 



thymicolymphaticus, 124 

 Internal secretion, definition and 



limitation of term, 5 



, doctrine of, date of origin, 4 



, when first formulated, 3 

 Interrenal body in fish, experimental 



extirpation, 150 

 bodies, accessory, 131, 134 

 , compensatory hypertrophy of 



portions of, 268 



in fish, experimental extirpa- 



tion, fatal, 152 

 structures, accessory, 268 

 , connection of suprarenal 



capsules with, 268 



systems, 129-131, 267-270 

 , development, 131, 132 



, functional significance of free 



portions, 268 



- , function of theory as to, 292- 



294 



tissue, importance of to life, 302 

 Interrenals, accessory, in white rats, 



*S5 



Intestinal canal, formation of products 



of decomposition in, 7 

 mucosa, secretion, mechanism of, 



440 

 tract, atrophy present in senile 



degeneration, absent in myx- 



cedema, 76 

 Intestines, action of adrenalin on, 



determined by experiment, 204 



Intracranial blood-pressure, conditions 

 governing, 329 



Invertebrates, adrenal system in, 135 



, suprarenal systems in, tables illus- 

 trating, 135-137 



Invertin, action of, inhibited by levu- 

 lose, 419 



Iodine, distribution in human organs, 

 30 



in thyroid gland, 29, 30, 106 



- ., relation to goitre, 29, 30, 31 



lodine-thyroglobulin, 30 



, reduced in hyperplastic and ex- 

 ophthalmic goitre, 30 



lodization, process of, in thyroid 

 gland, 105 



lodothyrin, 30 



, administration of, after thyroid 

 suppression, 87 



, effects on circulatory apparatus, 

 in animals, 90 



, function, 37 



lodothyro-globulin, effects on circu- 

 latory apparatus, 89 



Ions, function of, n 



Islands of Langerhans, see Langer- 

 hans, islands of 



Isopathy, branch of homoeopathy, 2 



, defined, 2 



JECORIN, 286 



KETONURIA, experimental, difficult to 

 obtain, 420 



, symptoms of diabetes, 419 



Kidney, blood-supply to, action of 

 adrenalin on, 212 



, contracted, true hyperplasia of, 

 chromaffine tissue in, 263 



, disease of blood from subjects of, 

 containing lymphagogue sub- 

 stance, 444 



disease, condition of adrenal 



system in, 262 

 - , effects of pituitary extract on, 325, 



327 

 - , internal secretion, 440 



, effect of renal extract on, 



442 



, parenchyma of, reduction of, 

 effects, 444, 445 



, transplantation of suprarenal cap- 

 sules in, 170, 171, 172 



LACHRYMAL glands, action of adrenalin 



on, 212 



Lactic acid and respiratory centre, 15 

 Langerhans, islands of, concerned in 



internal secretory function of 



pancreas, 436, 437 

 , effect of injection of phlorizin 



and adrenalin on, 435 



- of intravenous injection of 



grape-sugar on, 435 



, function, 433, 434 



Lecithin, cholin combined with, in 



body, 278 



