INDEX 



599 



New-born infants, pineal gland in, 



35i 

 , sexually differentiated tissues 



in, 361 

 Nicotine, action of, altered by increase 



in doses of ergot, 231 



effects confined to vegetative ner- 



vous system, 195 

 , particular ganglion cells affected 



by, 194 

 Nitrogen, excretion after reduction of 



renal parenchyma, 445 

 , metabolism of, in Graves's disease, 



99 



Nutrient secretions and hormones, dis- 

 tinction between, 13 



OBESITY associated with hypophysal 

 changes, 345 



, origin of types of, 385 



5 reduction by thyroid extracts, 91 



Organic extracts, intravenous injec- 

 tion, effect on blood-pressure, 

 21, 22 

 j physiological action, 21, 22 



, toxic action, 21 

 Organotherapy, 20 



- after experimental extirpation of 



suprarenal capsules, 165-168 

 , failure in pancreatic diabetes, 423, 



, forerunners of, 2 



- in Graves's disease, 100 

 , uses of, ii 



Organs of body, chemical correlation, 



5 



, experimental extirpation, ad- 

 vantages, 18 



, by-effects, 19 

 j internal secretory, 6 



, partial destruction, 19 



, potential energy, 10 



Ossification, effect of extirpation of 

 thymus on, 117, 118 



, influence of generative glands in, 

 382 



- , retardation of, following thyroid- 

 ectomy, 63 



Osteomalacia, relationship to genital 

 glands, 387 



Ovarian extract, effects of, 380 



Ovaries, relationship of, to chlorosis, 

 388 



, transplantation of, 380 



Ovary, influence of X-rays on, 403 



, internal secretion of, 398-406 



, interstitial tissue of, 399, 402 



, relationship to menstruation, 381 



Ovotestis, 363 



Ovulation, connection of menstruation 

 with, 403, 406 



Ovum, nidation of, 408 



Oxidation, increased, following extir- 

 pation of pancreas, 420 



Oxybutyric acid, 419, 420 



PANCREAS, action of adrenalin on, 212 



Pancreas, agency in influence of thy- 

 roid apparatus on carbohydrate 

 metabolism, 430 

 , changes in, in diabetes, 432 

 , effects on metabolism, 70 

 , excretory ducts, experimental liga- 

 ture, results, 436 

 , absorption of fat after, 



437 

 , external secretion, mechanism of, 



439 



, extirpation, deposition of glycogen 

 in liver after, how effected, 430 



, experimental, change in meta- 

 bolism following, 420 

 , increased oxidation follow- 

 ing, 420 



. -, emaciation following, 420 



, partial, not followed by gly- 



cosuria, 415 



- -of large portions followed by 

 slight glycosuria, 416 



3 total, followed by cessation of 



fat absorption, 437 



-, followed by glycosuria, 413 ; 



see also Diabetes (pancreatic) 



, reduction of glycogen in 



liver under, 418 

 , function of, inhibitory, 211 

 , in relation to decomposition of 



sugar, 426 



, internal secretion of, 412 

 , inhibition followed by gly- 

 cosuria, 428 



of formation of sugar 

 in liver by, 430 



secretory activity of, action of 

 adrenalin and, 220 



- , inhibited by adrenalin, 

 221, 226 



, limiting action of adrena- 

 lin, 226 



- , elements of, 432-438 

 , function, 18, 421, 423 



, acini and islands of 



Langerhans concerned in, 436, 

 437 



, transplantation experimental, 422 

 - and metabolism of sugar, 424, 425 



and thyroid gland, relationship 



between, 69, 70 

 , see also Hormones, pancreatic ; 



Langerhans, islands of 

 Pancreatic extract, inhibition of 



adrenalin glycosuria by, 429 

 Paralysis agitans, cause of, 46 

 Parathyroid extract, 49 



, physiological activity, 49, 50 



, treatment by, of post-operative 



tetany, 49 



glands, accessory, 31 



, anatomy, 31 



, colloid in, 33 



, comparative anatomy, 34 



, development, 34 



, effect on metabolism, 70 



