

CONTENTS. 



Page. 



I. Introduction 7 



II. Historical 8 



III. Proteosuria and the Bence Jones protein 10 



IV. Theories as to the formation or nature of the Bence Jones 



protein 1 1 



V. The Bence Jones protein and multiple myeloma, myelopathic 



proteosuria (Kahler's disease) 13 



VI. Experimental. 



A. On the preparation of digestive products of osseoalbumoid. . 15 



1. Tryptic digestion 15 



2. Peptic digestion 16 



3. Summary of results of procedures A (1-2) 21 



B. Subcutaneous injection of products of the peptic digestion of 



osseoalbumoid 22 



1. First experiment 23 



2. Second experiment 26 



3. Third experiment 28 



C. Subcutaneous injection of products of the tryptic digestion 



of osseoalbumoid 30 



Summary of results of procedures B-C 34 



D. Leucocytic proteolysis of osseoalbumoid 35 



Summary of results of procedure D 37 



E. Subcutaneous injection of products obtained in the leucocytic 



proteolysis of osseoalbumoid 38 



F. Intravenous injection of products obtained in the leucocytic 



proteolysis of osseoalbumoid 40 



1. First experiment 40 



2. Second experiment 40 



3. Summary of results of procedures E-F 44 



G. Intraperitoneal injection of osseoalbumoid 44 



H. Intrapleural injection of osseoalbumoid 45 



Summary of results of procedures G-H 47 



VII. Summary of general conclusions 47 



VIII. Bibliography 49 



IX. Biography 65 



X. Publication 66 



211035 



