MOEBID GROWTH IN GENERAL. iO 



comata. It differs from the multinuclear giant-cells by its greater 

 bulk on the one hand, by its behaviour to^yards reagents on the 

 other. For while the giant-cells maintain their continuity under 

 all circumstances, the addition of a small quantity of acetic or 

 chromic acid suffices to separate the nucleated protoplasm into its 

 component cells. In these cases we may often see a shred of the 

 nucleated tissue bounded by an arcuate or crenated border of a 

 darker hue, where it is in contact with the acidulated fluid ; each 

 individual arc corresponding to an isolated segment of the circum- 

 ference of one of the constituent elements of the protoplasmic 

 mass (fig. 29). 



Endogenous cell-formation must also be regarded as a modi- 

 fied variety of fission. Should a cell with a Avell-defined limi- 

 tary membrane, such e.g. as an oldish epithelium or cancer-cell, 

 be stimulated to production, the process confines itself to its 

 inner, semi-fluid portion. 



It is here that the nucleus divides, and the protoplasm groups 

 itself round the newly-formed nuclei. The resistance of the 

 cell-membrane prevents the independent segments from separat- 



FiG. 30. 



t%9 9|co 



Endogenous cell-form atioii. a. Development of pus-corpuscles 

 in epithelial cells ; h. Brood-capsules. 



ing ; and thus we obtain a more or less characteristic example of 

 a par^?i^-ce/Z containing a hroocl of daiiglitev-cells (fig. 30 a). It 

 is self-evident that the daughter-cells are smaller in size than the 

 parent-cells; they are alw^ays round, and usually resemble pus 

 corpuscles. It by no means follows that every one of the nuclei 

 resultino; from fission of the orio-inal nucleus should become the 

 centre of a daughter^cell ; on the contrary, one or more nuclei 



