ORGANISATION AFTEll SUPPUEATION. 123 



a foreign body, only to be got rid of by suppuration. To this 

 group too belongs the process of repair in ulcers : in a word, 

 repair by second intention is synonymous with organisation after 

 suppuration. 



§ 100. We .have to do with a free surface yielding pus. 

 From countless points of this surface young cells are forcing 

 their way ; these are accompanied by a fluid mainly transuded 

 from the blood, and very rich in dissolved albuminous matters. 

 Sooner or later the frontier-line of the secreting surface exhibits 

 changes diametrically opposite to those which occurred when 

 the plastic exudation melted into pus. The cells close up their 

 ranks. A layer of embryonic connective tissue is formed, 

 which intervenes between the parenchyma of the organism on 

 the one hand, and the pus on the other. Any pus-corpuscles 

 which may be secreted after the completion of this membrane 

 must make their way through the layer of embryonal connec- 

 tive tissue ; this waxes thicker, and rises into small globular 

 protuberances, the so-called " fleshy wnrts," or " granula- 

 tions." These granulations are the physical basis of all further 

 evolution ; they produce both skin and cuticle, but before all, 

 new vessels. 



§ 101. Vasciilarisation, here as elsewhere, is the most powerful 

 agent in organisation. The reason why the massing together of 

 cells in large numbers is associated with increased frailty of the 

 individual elements, lies in the great difficulty with which an 

 abundant collection of cells, e.r/. the juis-corpuscles which unite 

 to form an abscess, can be supplied with nourishment, if indeed 

 their nourishment is possible at all. Should the collection be a 

 large one, the elements nearest its periphery will continue to get 

 what pabulum they require from the adjoining nutrient fluid^ 

 and to rid themselves of their excrementitious products. The 

 farther we advance inwards the greater do the obstacles in the 

 way of this interchange become ; the excreta accumulate ; the 

 pabulum has no access to the parts. The only way in which 

 these disastrous results may be avoided is by vascularisation, i.e. 

 the foi-mation of canals, through which the products of the 

 oro^ans of sanoruification mav be carried into the midst of the 

 territory requiring nourishment, and the excrementitious matters 

 from the interior of the same territory may be removed. In 

 this way even aggregates of embryonic tissue of considerable 



