184 GLANDULAH CAECINOMATA. 



of the sebaceous glands, in which we undoubtedly have more 

 epithelium than is strictly required to line the cavity a a seba- 

 ceous folHcle, but never — unless the atheromatous cyst has 

 become an epithelial cancer — any centrifugal budding forth from 

 the epithelial layer. 



§ 151. Connected with the above are cases in vhich an in- 

 dependent outgrowth of the secreting parenchyma undoubtedly 

 takes place, but in wliich we may reasonably hesiate before we 

 regard the newly-formed tubuli as true, i.e. ^ functionally 

 capable portions of the gland. Both the seb-ceous and the 

 sudoriparous glands may undergo a monstrous excess of develop- 

 ment in circumscribed portions of the skin, ant (especially the 

 former) form fungous tumours of great size, without any increase 

 in the amount of secretion being observable or the surface. In 

 the hypertrophy of the sebaceous glands mceover there is a 

 marked deviation from the normal plan o^ structure, viz. a 

 thickening of the connective tissue of the ollicular sacs. A 

 farther extension of this peculiarity leads t subepithelial sar- 

 coma of the glands, e.g. of the female brea^ a form of disease 

 to wdiich Billroth has on this account applil the name of ade- 

 noid sarcoma. 



§ 152. With the complete emancipatio from the physiolo- 

 gical purpose of gland-growth begins le domain of those 

 tumours wdiich I call adenojiata. Apaifi'om its stroma, the 

 adenoma consists of epithelial cells, whosfarrangement at once 

 recalls the epithelial lining of the tubui' or acinous glands. 

 The cells are, for the most part, grouped 'und a central axis, as 

 though they really included a tubular men; but the lumen 

 itself is either wholly wanting, or presenonly in an interrupted 

 form, plugged with mucous or colloid mier, and most assuredly 

 shut off from free communication w^ith the /erent duct of the gland. 

 It w^ould seem as though Nature had (tcerned herself mainly 

 wdth an unlimited production of new pdular tubuli, without 

 much caring what became of them. S seems to forget that a 

 proportionate development of blood- vesls and connective tissue 

 is indispensable for the due perfection of glandular parenchyma ; 

 and so, as the process continues, a ttf)ur extraordinarily rich 

 in cells is formed, too scantily provid however with vascular 

 connective tissue to enable its nution to be adequately 

 carried on throughout its entire subsice, and which therefore 



