192 



GLANDULAR CAECINOMATA. 



are embedded in the healthy parenchyma. Next to these come 

 similar foci of progressively increasing size, which ultimately 

 coalesce to form that part of the growth which protrudes like a 

 circular rampart on the surface of section when the tumour is 

 cut across. Farther inWards certain white lines, corresponding 

 to the larger trabeculse of the cancer- stroma, grow more dis- 

 tinct ; the reddish-grey infiltration fades, or is replaced by a 

 yellow marbling, due to the conversion of the cancer-cells into 

 granule-corpuscles (Carcinoma reticulatum of Muller). The 

 vessels too of the stroma, which were hardly to be seen in the 

 encircling rampart itself, become much more distinct, mingling 

 red lines and dots with the white trabeculas of the stroma, and 

 the yellow points of fatty change. Still nearer to the centre 

 these appearances also fade, leaving a white and lustrous hard 

 cicatricial tissue, which sends radiating prolongations from the 

 centre of the tumour towards its circumference. So that, even 

 with the naked eye, we can distinguish four zones which corres- 

 pond to a like number of stages in the growth of the cancer ; a 

 zone of development, a zone of acme, one of degeneration, and 

 one of cicatrisation. 



Fig. 61. 



Carcinoma simplex mammae, a. Development of nests of 

 cancer-cells; 6. Fully-developed cancer-tissue (cf. the 

 next); c. Commencing cicatrisation ; it also represents the 

 relation between stroma and cells in scirrhus ; d. Cancer- 

 cicatrix. t^. 



