LUPUS. 4h1 



to a variable distance into tlie siuTounding parts ; its progress 

 may be admirably watched in the adipose tissue which invests 

 the deeper sweat-glands; little round corpuscles make their 

 appearance between adjacent fat-cells, which they engirdle, before 

 entirely covering and masking them from view. On the other 

 hand, the cell-growth often extends deep into the subcutaneous 

 connective tissue along the afferent vessels ; in the interior of 

 the gland itself, the mass of newly-developed embryonic tissue 

 also exhibits a dendritic arrangement, the parent-trunk coinciding- 

 with the point of entrance of the afferent vessel. 



In proportion to this exuberant cell-growth at the peri- 

 phery of the glandular tubes and acini, the latter themselves 

 increase in bulk ; their shape is altered, they become knotty and 

 bulbous, as described above ; their cavities are obliterated, and 

 only their general arrangement can be traced ; the parenchyma 

 being grouped round a central point which corresponds to the 

 efferent duct. The cells of which the degenerated acini consist, 

 are not the same large, vesicular elements, which took up so much 

 space during the stage of primary enlargement. Their size is 

 only about double that of the embryonic cells ; they are con- 

 centrically aggregated into little groups ; we notice indications, 

 as it were, of a tendency towards a higher degree of epithelial 

 development ; but the cells never get beyond the stage of those 

 which make up the rete Malpighii. 



§ 346. It may be objected that lupoid nodules are not always 

 superficial, that they are often met with deep in the subcutaneous 

 connective tissue. To this objection I rejoin, that the sweat- 

 glands, in particular, may even normally lie very deep, and that as 

 they increase in size, they are necessarily dislocated in a down- 

 ward direction, just as happens in the case of atheromatous cysts. 

 Finally, I must not omit to state that the development of 

 granulation-tissue, in what is known as the hypertrophic variety 

 of lupus, extends far beyond the limits of the glands, and tliat this 

 granulation-tissue is capable of being converted into mature 

 connective tissue, forming indurations like those in elephantiasis. 

 But the lupoid nodule proper is always an adenoma of a sebaceous 

 or sudoriparous gland. 



The further destiny of the lupoid products is usually this : 

 the parenchyma proper undergoes fatty degeneration Avhile the 

 intermediate granulation-tissue is converted Into pus. The little 



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