SULPHUROUS ACID AND SULPHITES. 1017 



very slight reduction in volume, while sulphurous acid again showed 

 a diuretic effect. 



In the special Series XI no diuretic effect is shown; it must be 

 noted, however, that only three subjects took part in this experiment, 

 none of whom was in the original series, and the time of year also may 

 have influenced this result to the slight extent shown, inasmuch as 

 Series XI was conducted in the spring and Series VII in the winter. 



PRESENCE OF ALBUMIN. 



The data which have been recorded for Series VII and XI show 

 unmistakable evidence that the preservative in certain cases produced 

 albuminuria. In the cases in which traces of albumin are present 

 in the fore period, however, there is no proof that the condition was 

 accentuated by the preservative. A further study will be necessary 

 to definitely establish this point. 



MICROSCOPIC BODIES. 



In general, there is shown an increase in the various bodies indi- 

 cated in the routine examination, particularly in the case of mucous 

 strands and mucous cylindroids. There was no evidence shown which 

 would indicate any lesions produced, as would be evidenced by a 

 largely increased production of the various casts, but the data taken 

 as a whole indicate a strong tendency on the part of the preservative to 

 produce an increased renal activity as evidenced by the general 

 increase of the microscopic bodies. 



DISTRIBUTION OF NITROGENOUS BODIES. 



In the special study (Series XI) made to determine the effects of 

 the preservative on the distribution of the nitrogen-bearing bodies 

 in the urine, there is shown a decrease in the quantity of urea excreted 

 during the preservative period. There is also a decrease in the total 

 nitrogen excreted which is contrary to the tendency shown in Series 

 VII. For the reasons given under the discussion of the volume of 

 the urine the data for Series VII must be given greater weight. 



The other bodies remain very constant. There is a tendency to 

 slightly decrease the amounts of uric acid and ammonia, under the 

 influence of the preservative, while kreatinin is slightly increased. 

 This disturbance, the decrease of urea and the increase of kreatinin, 

 shows an interesting relation in so far as the normal processes in 

 regard to the excretion o*f these bodies is concerned. Urea, which of 

 all the materials excreted contains the largest amount of nitrogen, is 

 believed by some to be an indication of the proteid metabolism. 

 Recently the excretion of kreatinin has received more attention and 

 is regarded by Folin and others as an index to katabolic changes, as 

 during normal metabolism it should remain constant. 



