150 Heredity and Eugenics 



found. Castle has made extensive transplantations of 

 ovaries, especially in guinea-pigs, and finds that : 



Out of seventy-four cases six died as the immediate result of the 

 operation; four of these were cases in which a ventral incision was tried. 



Summarizing the results of his operations he finds that in 



the results of the entire series only one grafted animal had young 

 from her grafted tissue; grafted ovaries fimctioned in six other cases, 

 but did not produce yoimg. Ten animals regenerated their own ovaries, 

 and three of these had young. Forty-two showed post-mortem com- 

 plete atrophy of the genital tract and absence of ovarian tissue. The 

 remainder comprises fifteen cases in which results were not fully deter- 

 mined. 



On January 6, 1909, the left ovary was removed from an albino 

 guinea-pig (Fig. 585), then about 5 months old, and the ovary of a pure 

 black guinea-pig about a month old (Fig. 58^!) was fastened near the 

 tip of the uterine horn, distant a centimeter or more from the site of the 

 ovary removed. One week later, January 13, a second operation was 

 performed, in which the right ovary of the albino was removed, and as 

 a graft was introduced the ovary of a second young black guinea-pig 

 of like age with the first but of different ancestry. After the albino 

 had full}^ recovered from the second operation she was placed with an 

 albino male (Fig. 58C), with which she remained until her death about 

 a year later. 



On the 23d of July, 198 days after the first operation, she gave 

 birth to two female young. One was black, but bore a few red hairs. 

 A photograph of this animal at the age of two or three months is showoi 

 in Fig. 58Z). The other young one was likewise black, but had some 

 red upon it, and its right forefoot was white (Fig. 58£). 



On October 15 the grafted albino bore a third young one, a male, 

 which, like those previously born, had a few red hairs interspersed with 

 black. A photograph of this animal is shown in Fig. 58F. 



On January 11,1910, the grafted albino was observed to be pregnant 

 for the third time, and this time she was very large. Unfortunately, 

 on February 2, she died of pneumonia with three full-grown male 

 young in utero. The skins of these animals were saved and a photo- 

 graph of them is sho\\Ti in Fig. 58G, H, and A'. Like the other three 



