PATHOLOGICAL LEUCOCYTES 

 SCHEME OF SCHILLING-TORGAU 



229 



Type of cell Normal Percentage , 



percentage 



1. Mast cells. x x 



2. Eosinophiles. , i e 



f a. myelocytes. o 0.5 



Neutro- ' b ' immature fon ns (metamye- 



' ~ 



philes oc y e s. o 5.0 



I c. bandform (Stabkernige). 4 I3 .5 



[ d. multilobed (Segmentkernige) . 63 64.0 



4. Lymphocytes. 23 10.5 



5. Large mononuclears and transitionals. 6 4.0 



PATHOLOGICAL LEUKOCYTES 



The leukocytes which are found in the peripheral circulation only 

 in pathological conditions are: 



1. Neutrophilic Myelocytes. The common type is a large cell 

 with a large centrally placed, feebly staining nucleus. 



This may be recognized by the difficulty of distinguishing the nucleus from 

 the cytoplasm, there being no sharp line separating these parts of the cell. They 

 imperceptibly merge into one another. They differ from a large mononuclear in 

 that the cytoplasm is distinctly dotted with neutrophile granules and that we 

 cannot make out a distinct line of separation of a slightly irregular or indented 

 nucleus from the surrounding slightly neutrophilic cytoplasm. Cornil has described 

 a very large myelocyte with eccentrically placed nucleus and neutrophilic granules. 



Myelocytes are at times found with both basophilic and neutrophilic 

 granules, and may rarely be seen to have all three kinds of granules on a 

 single myelocyte, acidophile, basophile, and neutrophile. 



2. Eosinophilic Myelocyles. These can be distinguished from 

 normal eosinophiles by their possessing a single round nucleus, not 

 bilobed. These myelocytes may be as large as a normal eosinophile, 

 but frequently are no larger than a red cell. 



The neutrophile myelocyte is characteristic of spleno-myelogenous leukaemia, the 

 eosinophile one of myelogenic leukaemia. The occurrence of an occasional myelocyte 

 is frequently noted in conditions having a leukocytosis. In diphtheria their presence 

 in numbers is of bad prognostic import. Myelocytes are of diagnostic importance 

 in metastases of malignant tumors. 



3. The Irritation Cell of Tiirck, or Plasma Cell. This cell has a 

 faintly staining, eccentrically placed nucleus, and a dark opaque blue, 

 frequently vacuolated, cytoplasm. They are usually recorded as large 



