LEUKAEMIA 



239 



blasts may rarely be found. The red count is usually about 2,500,000 and the 

 color index low. 



Lymphatic Leukaemia. In this we have glandular enlargements, 

 but not such large masses as in Hodgkin's disease. The red cells are 

 usually reduced about one-half and the color index is a little below 

 normal. Normoblasts are rarely found. Myelocytes, as a rule, are 

 absent, but may amount to 5% of the leukocytes. The predominating 

 leukocyte (75 to 98%) is the small lymphocyte. In acute lymphatic 

 leukaemia the large lymphocytes predominate. 



FIG. 57. Myelogenous leukaemia, m, Myelocyte; p, polymorphonuclear; b, mast 

 cell; n, normoblast. (Cabot.) 



These however are pathological and differ from the large lymphocyte in not 

 having azur granules and the nucleus stains poorly and is often indented. The 

 leukocyte count is never so great as in myeloid leukaemia, rarely exceeding 125,000. 



Pseudoleukaemia. Hodgkin's disease is usually considered as a 

 disease with marked glandular enlargements, but with a negative blood 

 picture, or at any rate only a moderate leukocytosis with a relative 

 increase of lymphocytes. 



The glands in this condition do not soften and on section show diffuse hyper- 

 plasia of cells of the endothelial type. Eosinophiles are also abundant in the sec- 

 tions. Connective-tissue increase and small necrotic areas are also features. 



The red cells are usually above 3,000,000. It has been considered that an in- 

 creased percentage of transitionals (10 to 15%), should a leukopenia coexist, is 

 characteristic. 



Undoubtedly the view that so-called lymphosarcomata, lymphatic 

 leukaemia, and Hodgkin's disease merge into one another and that they 



