240 NORMAL AND PATHOLOGICAL BLOOD 



represent a malignant cell formation in the haemopoietic system is 

 conservative one to take. 





A certain proportion of cases of Hodgkin's disease, however, show endothelial 

 cell proliferation and a chronic fibroid change. 



In Kundrat's lymphosarcoma we have a neutrophile leukocytosis 

 and a diminution of the lymphocytes. The spleen and liver are rarely 

 involved. 



Another condition with swelling of the lymphatic glands, which do not however 

 fuse, is the so-called granulomatosis. 



FIG. 58. Lymphatic leukaemia. />, polymorphonuclear; m, megaloblast; e, eosino- 

 phile. Twenty-one lymphocytes in this field. (Cabot.) 



In this we have a polymorphonuclear leukocytosis of from 20,000 to 50,000 with 

 an increase in the percentage of eosinophiles. The lymphocytes are absolutely and 

 relatively decreased. In granulomatosis there is no tendency to haemorrhage. 



Splenomegaly. The best known anaemia associated with splenic 

 enlargement is Band's disease. 



Banti's disease also has a very low color index and leukopenia. In 

 this the primary affection is of the spleen which becomes greatly en- 

 larged. The accompanying cirrhosis of the liver with its symptoms of 

 ascites, etc., differentiate it. Splenectomy often cures the disease. 

 The leukopenia is one showing not only a diminution of polymorphonu- 

 clear percentage but of cells of the lymphocyte type as well. 



There is a considerable increase in the large mononuclear percentage. Nucleated 

 reds and myelocytes are invariably absent. It must be remembered that we have a 

 group of cases showing splenomegaly which are syphilitic in origin and which, as a 

 rule, give a positive Wassermann. Clinically or haematologically they resemble true 



