428 



GLOBULIN INCREASE TESTS 



" 



a few seconds at the junction. Normally there is no sign of a ring. This test 

 modification of Nonne's Phase I reaction. 



A test that is not in general use is strongly recommended by Miller. It is known 

 as Pandy's test. To carry it out prepare a saturated solution of carbolic acid crystals 

 in distilled water. Place i c.c. of this reagent in a small test-tube and add i drop 

 of spinal fluid. In a normal fluid only the faintest opalescence is observed, but in 

 a fluid with globulin increase a smoke like white cloud developes instantly where 

 the drop comes in contact with the reagent. Miller gives the following table as 

 showing the average frequency of the various reactions in syphilis of the central 

 nervous system. 



SHOWING THE AVERAGE FREQUENCY OF THE VARIOUS REACTIONS IN SYPHILIS 

 THE CENTRAL NERVOUS SYSTEM 



Poliomyelitis in addition to small mononuclear increase together with rather 

 characteristic large mononuclear cells shows a globulin increase. 



Urea Content. Any excess of urea in the cerebrospinal fluid is a sure 

 sign of renal inadequacy. 



Normally the urea content of cerebrospinal fluid is only 0.006%, 

 according to Canti. Cases of true uremia, and not renal disease 

 associated with cardio- vascular disease, show from o.i to 0.6%. 

 Cases showing over 0.3% rarely recover. The estimate may be made 

 from 5 c.c. of spinal fluid by the urease method. 



