NATURAL AND CASUAL COW-POX. 319 



the teats as it is ordinarily met with ; the other is a composite picture, 

 consisting of the disease as ordinarily observed in the cow, to which 

 is superadded a number of depressed vesicles as they occur in inocu- 

 lated cow-pox. It is, however, an improvement on a plate published 

 by Sacco. The latter is an elaborate drawing, representing the udder 

 and teats of a cow, with an eruption purporting to be the natural 

 cow-pox. Jenner had described a bluish tint in the vesicles in 

 natural cow-pox, arid Sacco deliberately represents the natural disease 

 by a highly coloured diagrammatic illustration in which he depicts 

 clusters of vesicles of inoculated cow-pox, coloured blue, and with 

 a silvery lustre. 



Hering has given a coloured plate of the natural cow-pox. On 

 the teats are a number of oval and circular bullous vesicles and 

 crusts. More recently, Layet has pointed out the same characters 

 in the cow-pox discovered near Bordeaux in 1883 and 1884. The 

 classical characters of the inoculated disease were wanting, particu- 

 larly the central depression. In Wiltshire, the author could only 

 distinguish, on the cow's teats, globular and broken vesicles and 

 thick prominent crusts and ulcers, appearances which had very 

 little in common with the ordinary results of vaccination. 



The early accounts of the severe character of the disease will 

 appear by no means exaggerated to those who have had an oppor- 

 tunity of studying the effects on the hands of the milkers, or indeed 

 to those who have made themselves familiar with the descriptions 

 given by Jenner, in some of his cases : 



" Joseph Merret had several sores on his hands, swelling and stiffness 

 in each axilla, and much indisposition for several days. 



" Mrs. H. had sores upon her hands which were communicated to her 

 nose, which became inflamed and very much swollen. 



" Sarah Wynne had cow-pox in such a violent degree that she was 

 confined to her bed, and unable to do any work for ten days. 



" William Rod way was so affected by the severity of the disease that 

 he was confined to his bed. 



" William Smith had several ulcerated sores on his hands, and the 

 usual constitutional symptoms, and was affected equally severely a second 

 and a third time. 



" Wrlliam Stinchcomb had his hand very severely affected with several 

 corroding ulcers, and a considerable tumour in the axilla. 



" Sarah Nelmes had a large pustulous sore on the hand, and the usual 

 symptoms. 



"A girl had an ulceration on the lip from frequently holding her 

 finger to her mouth to cool the raging of a cow-pox sore by blowing 

 upon it. 



