452 



INFECTIVE DISEASES. 



nostrils and swelling of the glands, and nothing more will be visible 

 until a post mortem examination has been made. 



Glanders in man is found amongst those whose duties bring 

 them into contact with diseased horses, such as stable-men, cavalry 

 soldiers, and veterinary surgeons ; and it is generally the result 

 of accidental inoculation of a wound. An abscess develops, followed 

 by metastatic purulent infiltration of the lungs, liver, spleen, and 

 bones. There may be cedeinatous swelling of the face and ulcers 

 in the nostrils. The joints may become swollen and painful. 



The nodules consist of fibrous tissue and cells, with a tendency to 

 suppuration. In the lungs the disease spreads by the lymphatics. 



iff; 



*. 

 ifer^ 



FIG. 184. BACILLI OP GLANDERS ; section of a glanders nodule, x 700 (FLUGGE).. 



The infiltrated patches are necrosed in the centre, which is sur- 

 rounded by leucocytes and fibrous tissue. 



The bacilli were discovered by Loffler and Schutz in 1882. They 

 are found in the discharge from the nostrils, in the pus, and in the 

 nodules of animals artificially infected. 



Bacillus mallei Rods, with rounded ends, shorter and 

 thicker than the .tubercle bacillus, occurring singly, or in pairs, 

 and sometimes in filaments. The protoplasm in the rod is broken 

 up in stained preparations, as in the tubercle bacillus. They stain 

 with the watery aniline dyes, and intensely so with alkaline methylene 

 blue or Neelsen's solution ; they are non-motile and aerobic ; spore 

 formation has been described. They can be cultivated on the usual 

 media, especially on glycerine-agar and on potato ; but they will not 

 grow in infusions of hay, straw, or stable manure. On the surface 

 of glycerine-agar a colourless, transparent growth occurs on either 



