THE BACTERIOPHAGE IN DISEASE 



177 



of symptoms. Within one or two days after the onset all had 

 again become normal. In only one or two cases did the stools 

 contain traces of blood. In order to establish a diagnosis the 

 directrix was asked to send a patient to the Hospital during the 

 earliest symptoms. 



Germaine Mel. . . . entered the Hospital on the 18th of July. 

 From the first stool passed after her arrival a bacillus presenting 

 the biochemical characteristics of the Shiga bacillus was isolated 



Day of the Disease 



eo 



FIG. 1. GERMAINE MEL. . . . DYSENTERY (SHIGA) 



B. dysenteriae from the patient- 

 Virulence for "I B. dysenteriae, stock strain 

 B. coli. . 



after considerable difficulty. It was inagglutinable, and it was 

 only after three passages on agar that agglutination was secured 

 (1:500). 



As can be seen in the tracings, the number of fluid stools, 

 seventeen on the first day, fell quickly during the second day 

 to two, without medication. 



The intestinal bacteriophage, isolated from the fifth stool of the 

 first day, was endowed with an extreme virulence for the bacillus 



