268 THE BACTERIOPHAGE 



Julien D. . . . (three and one-half years). This was a case of very 

 severe dysentery. The general condition of the patient was very bad. 

 A sister of the patient had died at home of dysentery on September 8. 



From the llth to the 13th of September the number of stools, all of which 

 were bloody, could not be counted. 



September 13. The patient entered the hospital. Examination showed : 

 B. dysenleriae Shiga present, the dysentery bacilli constituting about 4 

 of every 5 colonies on the plates. 



The intestinal bacteriophage was without activity for either B. coli 

 or the dysentery organisms. 



September 13. The patient ingested 2 cc. of anti-Shiga bacteriophage 

 culture at 5 o'clock. This culture had been lysed for fifteen days. 



September 14. There were 6 bloody stools. The intestinal bacterio- 

 phage showed virulences as follows: B. coli +++, Shiga +++, Flexner 

 ++, Hiss +. 



September 15. During the day there was one bloody stool. There were 

 also 5 stools without blood. Examination showed: B. dysenteriae Shiga 

 absent. 



The intestinal bacteriophage with activities as follows: B. coli + +++, 

 Shiga + +++, Flexner + ++, Hiss +++. 



September 16. There were 4 stools, all without blood. The intestinal 

 bacteriophage showed: B. coli ++++, Shiga ++++, Flexner ++, Hiss 



September 17. During the day there were one fluid stool and 2 formed 

 stools. The intestinal bacteriophage showed: B. coli +- f-++, Shiga 

 ++++, Flexner ++, Hiss +. 



September 18. There were 2 formed stools. The intestinal bacterio- 

 phage was virulent as follows: B. coli ++++, Shiga ++++, Flexner +, 

 Hiss ++. 



September 26. The patient was discharged from the hospital. On 

 this date the virulence of the intestinal bacteriophage was: B. coli +++ 

 Shiga 0, Flexner 0, Hiss-f. 



Emile D. . . . (seven and one-half years). This patient was a brother 

 of the preceding case, and showed a very severe dysentery. On the llth 

 and 12th of September there were 20 to 25 fetid stools, fluid but not bloody. 



September 12. Examination showed that the Shiga bacilli were very 

 abundant. The intestinal bacteriophage was inactive for B. coli or for 

 the dysentery organisms. 



September 13. There were 25 bloody stools. At 5 o'clock the patient 

 ingested 2 cc. of bacteriophage culture. The culture had been lysed for 

 six and one-half months. 



September 14. There were 4 bloody stools in the morning and 2 stools 

 without blood in the afternoon. Examination of one of the latter showed 

 no Shiga bacilli. The virulences of the intestinal bacteriophage were: 

 B. coli ++++, Shiga ++++, Flexner ++, Hiss + ++. 



