SWINE PLAGUE 67 



a few cases the local lesion persisted a considerable length of 

 time. It was quite severe in all fatal cases in which the disease 

 was prolonged several weeks after inoculation, although the 

 real cause of death was due in all such cases to localizations on 

 one or more of the serous membranes. The peculiar forms of 

 disease may be grouped as follows : 



(a) Persistence of local lesions. — Rabbit No. 50 received in the ab- 

 dominal cavity 3.5 cc. of the sterilized suspension of agar cultures in 3 

 doses. It was subsequently inoculated beneath the skin vyith o.ooi cc. 

 of a bouillon culture of swine-plague bacteria which produced a large 

 local swelling. On February 25, 1S92, nearly eight months after its 

 inoculation it was chloroformed. The only lesion found was in the 

 subcutaneous tissue. At the point of inoculation the skin was sloughed 

 over an area of 3 cm. in diameter. This denuded surface was covered 

 with a thick scab. The subcutis beneath the scab and surrounding the 

 ulcer was infiltrated with pus. A stained cover-glass preparation showed 

 swine-plague bacteria. No other lesions were found. 



{b) Sub-peritoneal abscess. — Rabbit No. 16 was injected intraven- 

 ously with 16 cc of sterilized bouillon cultures of swine-plague bacteria. 

 After some days it was inoculated beneath the skin with o.ooi cc. of a 

 fresh bouillon culture of virulent swine-plague bacteria. The control 

 rabbit died within twenty hours. Rabbit No. 16 showed no ill effect 

 from the inoculation for several months when it was noticed that it was 

 becoming emaciated. It died June 11, 1892, one year and six days after 

 its inoculation with an enormous subperitoneal tumor. 



(c) Multiple abscesses under the skin. — Rabbit No. 439 received into 

 the ear vein in three injections 4 cc. of sterilized blood from a swine 

 plague rabbit. Later it was inoculated subcutaneously with 0.001 cc. of 

 a bouillon culture of virulent swine-plague bacteria. The control rabbit 

 died within twenty hours. Two months after the inoculation it was 

 noticed that this rabbit with others was suffering from a large number 

 of subcutaneous abscesses. " 



REFERENCES. 



1. DE ScHWEiNiTz. Serum therapy. Proceedings Society for the 

 Promotion of Agricultural Science. 1896. p. 47. 



2. DE ScHWEiNiTZ. The serum treatment of swine plague and 

 hog cholera. Bulletin No. 23. U. S. Bureau of Animal Industry. 1S99. 



3. LoEFFLER. Arbeiten a. d. Kaiserlichen Gestmdheitsamte. Bd. I 



(1885) S. 5t. 



4. MooRE. Pathogenic and toxicogenic bacteria in the upper air 

 passages of domesticated animals. Bulletin No. 3. U. S. Bureau of 

 Ani)nal Industry. 1893. ' 



5. Moore. Concerning the nature of infectious swine diseases in 

 the State of New York with practical suggestions for their prevention 

 and treatment. Report of the New York State Commissioner of Agri- 

 culture. 1897. 



