MORBID ANATOMY 227 



apparaiitly gives considerable rigidity to the cells, as nearly all 

 of them are approximately circular in form. Their average 

 diameter is about 8 microns. In one specimen there appeared to 

 be large giant cells, measuring from 12 to 1 8 microns and appar- 

 ently possessing quite a distinct cell wall. Within each giant 

 cell there is some appearance of vacuolated cells, each with a 

 single nucleus and fairly well-defined cell boundary. As many 

 as eight or ten of these nuclei have been counted in a single 

 giant cell. There is the possibility that these apparent giant 

 cells are simply some of the vacuolated cells fused together, 

 but the nuclei are well defined and take the stain very intensely, 

 which is not commonly the case in the ordinary vacuolated 



cells. 



The connective-tissue cells surrounding the nodule show 

 marked signs of degeneration, their cytoplasm in most cases 

 being extremely vacuolated. Among these connective-ti.ssue 

 cells, which for the most part are quite branching and elon- 

 gated, is another class of cells which are in general of an oval 

 or elliptical form. The noteworthy appearance of these cells 

 is the presence of numerous dots in the cytoplasm which take 

 the methylene blue and toluidin blue stains very deeply. The 

 appearance is, indeed, very much as if the cells were filled 

 with micrococci. These are the granule cells of Waldeyer, or 

 still further differentiated as the plasma cells, in contradis- 

 tinction to the "mastzellen" or "food" cells," which indicate 

 an exalted degree of nutrition. The nucleus of the plasma 

 cell takes the stain very slightly, or not at all, and is almost 

 entirely obscured by the numerous "granules" in the cyto- 

 plasm. These cells are well differentiated by the toluidin blue 

 stain, as they take a deep purple color, while the surrounding 

 cells are blue. 



Bitting has figured the jaw bone of a horse quite exten- 

 sively affected with this disease. He believes that the lesions 

 about the mouth result from the animal biting the affected 

 areas on the body. 



Neyrick reports finding the inflammatory growths in the 

 lungs of an affected subject and Burke has reported them in 



