HISTOLOGY 235 



seen, there were innumerable free spores as well as those still 

 attached to the sterigmata, but in no case were spores detected 

 in the substance of the tissues. 



In many sections, especially those from near the center 

 of the nodules, the mass of mycelium was so dense that 

 the structure of the tissues was obscured. Besides the dense 

 growths resembling actinomycosis already described, other 

 brush like clusters not unlike them were frequently seen. 

 These differ from the former in being somewhat less com- 

 pact, and that from their periphery numerous hyphae run out 

 into the surrounding tissues, whereas in the actinomycotic 

 form the masses are sharply defined and only here and there 

 a few threads grow out beyond the cluster. Their appearance 

 suggests that the}^ may be actinomycotic forms which have 

 finally overcome the resistance of the tissues. Emphysema is 

 less marked in the neighborhood of the latter. 



The cow was examined carefully for the lesions of tuber- 

 culosis and in one lung some four or five caseous and calcareous 

 nodules i cm. in diameter were found in which tubercle bac- 

 teria were demonstrated, but no mycelium could be detected. 

 In no part of the lung was there coexistence of the two 

 infections. 



The fact that the animal did not react to tuberculin, 



though tuberculosis was present, is noteworthy and suggests 



that the mould infection may interfere with the test. It adds 



a possible source of error in the tuberculin test to be guarded 



against. 



REFERENCES. 



1. Arwine AND Lamb. A fifth case of "fungous foot" in America. 

 The Am Journ . of Med. Sciences. Oct., 1S99. 



2. DiNWiDDiE. On the toxic properties of moulds. Bulletin No. 

 10, Arkansas Agric. Exp. St a. May, 1896. 



3. Flexner. Pseudo-tuberculosis Hominis Streptothricha. The 

 Journal of Experimental Medicine. Vol. III. (1S98) (Bibliography). 



4. Ophuls and Moffitt. a new pathogenic mould. The Philadel- 

 phia Med. Journal. June 30, 1900. 



5. Pearson and Ravenel. A case of pneumonomycosis due to 

 the Aspergillus fumigatus. The University Medical JMagazine. Aug., 

 1900. The. Vet. Journal, New Series. Vol.11. (1900) p. 229. 



6. Renon. L'Etude sur TaspergiMose chez les animaux et chez 

 rhomme. 1897. 



7. Weis. Four pathogenic Touruke (Blastomycetes). The Jour, 

 of Med. Research. Vol. VII. (1902) p. 280. 



