3l8 RABIES 



the dilated pericellular lymphatic spaces by a multiplication of 

 small nuclei. 



6. The lesion of medullary substance is less pronounced, 

 it consists chiefly of an oedema of the medullary sheath of the 

 nerve fibers. 



7. In certain plasma cells, in the interior of and around 

 vessels, sometimes in leucocytes, in lymphatic spaces, in the 

 altered parts of certain nerve cells, and in the dilated sheath 

 of nerve fibers may be seen round or amoeboid granules about 

 in in diameter, pigmented or stainable bj' aniline dyes, and 

 which in part seem to posses the power of movement. 



More recently Babes has noted, besides the lesions above 

 mentioned, that the alteration of the nerve cell is usually 

 accompanied by a modification of their protoplasmic network 

 and concludes that "Whilst admitting that the lesions of rabies 

 are not absolutel3^ characteristic, and that it may be that in a 

 case ot diffuse, very acute myelitis similar lesions may be 

 found, it is necessary all the same to state, that neither in 

 writing nor in my personal experience have I ever met with a 

 similar case, so that at present we may consider the lesion of 

 rabies as characteristic. In other infectious diseases there 

 have also been found histological lesions characteristic as a 

 whole, although composed of elements not absolutely specific." 



Golgi draws attention to the followingmorbid changes in 

 rabies : 



(i) Changes in the structure of the nucleus, all the vari- 

 ous phases of karyokinesis may be simulated, yet no true 

 nuclear division may take place. (2) Changes in the body of 

 the cells, such as vacuole formation, bladder-like transforma- 

 tion of the cells. Changes may also be recognized by methods 

 directed to the study of the outer form of the cell. Here 

 varicose appearances of the cell processes may be seen. 

 Granular fatty changes ma}' also be present. An important 

 change lies in the displacement of the nucleus. The periphery 

 of the cell becomes homogeneous. Granular fatty changes 

 are also seen in the neuroglia cells. (3) Changes in the inter- 

 vertebral ganglia. The author would look upon these ana- 

 tomico-pathological changes found by him as characteristic, 



