PSEUDOMONAS CERUGINOSA. 309 



found in an extensive purulent infiltration of the tissues 

 and a marked zone of inflammatory oedema. 



When introduced directly into the peritoneal cavity 

 the results are also fatal, and at autopsy a genuine 

 fibrinous peritonitis is found. There is usually an ac- 

 cumulation of serum in both the peritoneal and pleural 

 cavities. At autopsies after both methods of inocula- 

 tion the organisms will be found in pure cultures in 

 the blood and internal viscera. 



When animals are inoculated with small doses (less 

 than 1 c.c. of a bouillon culture) of this organism death 

 may not ensue, and only a local inflammatory reaction 

 (abscess-formation) may be set up. In these cases the 

 animals are usually protected against subsequent inocu- 

 lation with doses that would otherwise prove fatal. 



Most interesting in connection with pseudomonas 

 ceruginosa is the fact, as brought out in the experiments 

 of Bouchard, and of Charrin and others, that its prod- 

 ucts possess the power of counteracting the pathogenic 

 activities of bacterium anthrads. That is to say, if an 

 animal be inoculated with a virulent anthrax culture, 

 and soon after be inoculated with a culture of pseudo- 

 monas ceruginosa, the fatal effects of the former inocu- 

 lation may be prevented. Emmerich and Low ' are 

 inclined to attribute this to the direct bacteriolytic action 

 of the enzymes upon the anthrax bacteria introduced 

 into the tissues. 



In the literature upon the green-producing organisms 

 that have been found in inflammatory conditions sev- 

 eral varieties believed to be distinct species have 



1 Munchener med. Wochenschrift, 1898, No. 40 ; Centralblatt fur 

 Bakteriologie und Parasitenkunde, 1899, Abt. i. No. 1, p. 33. 



